摘要
目的观察阿司匹林与氯吡格雷联合治疗脑梗死的临床效果以及对MoCA、NIHSS评分和血液流变学的影响。方法选择2018年1月—2019年12月期间在我院治疗的100例脑梗死患者作为研究对象,按治疗方式的不同将其分为对照组(予以阿司匹林治疗)和观察组(予以阿司匹林联合氯吡格雷治疗),每组50例。比较两组治疗前后的蒙特利尔认知评估量表(MoCA)、美国国立卫生院神经功能缺损评分(NIHSS)和全血粘度、血浆粘度、红细胞沉降率以及不良反应发生情况。结果治疗前,两组的MoCA、NIHSS评分和全血粘度、血浆粘度、红细胞沉降率比较,差异无统计学意义(P>0.05);治疗后,观察组的MoCA评分高于对照组,且NIHSS评分低于对照组(P<0.05);观察组的全血粘度、血浆粘度、红细胞沉降率均低于对照组(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论阿司匹林联合氯吡格雷治疗脑梗死,能有效改善患者的血液流变学状况,修复受损的神经,改善认知功能,且安全性好。
Objective To explore the clinical effect of aspirin combined with clopidogrel in the treatment of cerebral infarction and its influence on MoCA,NIHSS score and hemorheology parameters.Methods 100 patients with cerebral infarction treated in our hospital from January 2018 to December 2019 were selected and divided into the control group(treated with aspirin)and the obsevation group(treated with aspirin combined with clopidogrel),50 cases in each group.The Montreal Cognitive Assessment Scale(MoCA),NIHSS score,whole blood viscosity,plasma viscosity,erythrocyte sedimentation rate and adverse reactions were compared between the two groups before and after treatment.Results Be⁃fore treatment,there was no significant difference in MoCA,NIHSS scores,whole blood viscosity,plasma viscosity,and red blood cell sedimentation rate between the two groups(P>0.05).After treatment,the MoCA score of the observation group was higher than that of the control group;the NIHSS score was lower than that of the control group(P<0.05);the whole blood viscosity,plasma viscosity and red blood cell sedimentation rate of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin combined with clopidogrel in the treatment of cerebral infarction can effectively improve patient's blood rheology,repair damaged nerves,improve cognitive ability,and have good safety.
作者
姚成柱
林伯昌
徐惠珍
YAO Chengzhu;LIN Bochang;XU Huizhen(The People's Hospital of Boluo County,Huizhou 516100,Guangdong)
出处
《菏泽医学专科学校学报》
2021年第1期31-33,共3页
Journal of Heze Medical College
关键词
阿司匹林
氯吡格雷
脑梗死
血液流变学
神经功能
不良反应
Aspirin
Clopidogrel
Cerebral infarction
Hemorheological parameters
Neurological function
Adverse reactions
