摘要
目的探讨前列腺病理大切片技术的临床应用及价值。方法回顾性分析我院行根治性前列腺切除术的155例患者的临床资料。所有患者术后均进行病理切片分析,根据病理切片方式将其分为大切片组(45例)和常规切片组(110例)。比较2组患者切片情况、术后病理特征及Gleason评分。结果2组切片均未见收缩或褶皱,结构完整,细胞形态清晰可见。其中大切片组可多层、全面地观察到前列腺病变情况,准确定位病灶,直观辨别微小病灶、前列腺切缘是否为阳性;常规切片组无法全面观察到前列腺病变情况及其与周围组织的关系,难以明确肿瘤与切缘的距离和切缘是否为阳性。大切片组切缘阳性、微小病灶、精囊侵犯检出率高于常规切片组(P<0.05),但2组病理分期检出率比较,差异无统计学意义(P>0.05)。2组手术前后Gleason评分比较,差异无统计学意义(P>0.05),但大切片组术后Gleason评分升高比例高于常规切片组(P<0.05)。结论前列腺病理大切片技术可以全面观察到前列腺组织,提高切缘阳性、微小病灶及精囊侵犯检出率,为前列腺癌患者术后局部精准治疗提供病理依据。
Objective To explore the clinical application and value of large section technique for prostate pathology.Methods The clinical data of 155 patients who were treated with radical prostatectomy in our hospital were retrospectively analyzed.All the patients underwent pathological section analysis after operation,and they were divided into the large section group(45 cases)and the routine section group(110 cases)according to the pathological section method.The section status,postoperative pathological characteristics and Gleason scores were compared between the two groups.Results There was no shrinkage or wrinkle in sections of the two groups,with complete structure and clear cell morphology.In the large section group,the prostate lesions could be comprehensively observed in multiple layers and accurately located,and the small lesions and whether the incisal margin of the prostate was positive could be distinguished directly.In the routine section group,the prostate lesions and their relationship with surrounding tissues could not be comprehensively observed,and it was difficult to determine the distance between the tumor and the incisal margin and whether the incisal margin was positive.The detection rate of positive incisal margins,small lesions and seminal vesicle invasion in the large section group were higher than those in the routine section group(P<0.05),but there was no statistically significant difference in the detection rate of pathological staging between the two groups(P>0.05).There was no statistically significant difference in Gleason scores between the two groups before and after operation(P>0.05),but the increase ratio of Gleason scores after operation in the large section group were higher than that in the routine section group(P<0.05).Conclusion Prostate pathological large section technique can fully observe the prostate tissues,and improve the detection rate of positive incisal margins,small lesions and seminal vesicle invasion,which provides a pathological basis for postoperative local precision t
作者
高闫尧
付强
胡伟
孙振业
严奉奇
王殊妹
赵秋香
王禾
GAO Yan-yao;FU Qiang;HU Wei;SUN Zhen-ye;YAN Feng-qi;WANG Shu-mei;ZHAO Qiu-xiang;WANG He(Department of Urology,Second Affiliated Hospital of Air Force Military Medical University,Xi’an Shaanxi 710038,China;Department of Pathology,Second Affiliated Hospital of Air Force Military Medical University,Xi’an Shaanxi 710038,China)
出处
《局解手术学杂志》
2021年第3期205-208,共4页
Journal of Regional Anatomy and Operative Surgery
基金
陕西省重点研发计划-一般项目-社会发展领域(2018SF-175)
空军军医大学第二附属医院科技创新发展基金-前沿探索项目(2019QYTS007)。
关键词
病理大切片技术
常规切片
前列腺癌
前列腺根治术
前列腺特异性抗原
病理检查
pathological large section technique
routine section
prostate cancer
radical prostatectomy
prostate-specific antigen
pathological examination
