摘要
目的:探讨红细胞RhE抗原匹配输血对卵巢癌患者围术期免疫功能及预后的影响。方法:回顾分析2017-01—2017-12接受手术治疗的卵巢癌患者,将RhE抗原为阴性且术中输注红细胞的90例作为研究对象。将受试者分为输注RhE阳性红细胞的观察组和输注RhE阴性红细胞的对照组,各45例。比较2组患者输血前、后淋巴细胞水平及预后情况。结果:NK细胞、B细胞、CD3^(+)T细胞、CD4^(^(+))T细胞及CD4^(+)/CD8^(+)比值与输血前比较,观察组和对照组输血后1 d细胞水平均显著降低(P<0.01);输血后7 d逐渐升高,观察组与输血前比较差异有统计学意义(P<0.01),对照组与输血前比较差异无统计学意义(P>0.05);CD8^(+)T细胞2组输血前后比较差异无统计学意义(P>0.05)。输血前2组淋巴细胞比较差异无统计学意义(P>0.05);输血后1 d和7 d的NK细胞、B细胞、CD3^(+)T细胞、CD4^(+)T细胞及CD4^(+)/CD8^(+)比值,观察组明显低于对照组,差异有统计学意义(P<0.05);CD8^(+)T细胞比较差异无统计学意义(P>0.05)。术后感染率和术后2年复发率,观察组高于对照组,比较差异有统计学意义(χ^(2)=5.075,P<0.05;χ^(2)=9.87,P<0.01)。结论:红细胞RhE抗原非匹配输注可以使RhE阴性卵巢癌患者围术期免疫功能明显下降且恢复不良,增加患者术后感染率和2年复发率。
Objective:To investigate the effects of RhE antigen matching transfusion on perioperative immune function and prognosis of ovarian cancer patients. Method:A retrospective analysis was performed on the ovarian cancer patients who underwent surgical treatment in our hospital from January 2017 to December 2017,and 90 patients with RhE antigen negative were included in the study.The subjects were divided into observation group receiving RhE-positive red blood cells and control group receiving RhE-negative red blood cells,with 45 cases each.The lymphocyte levels and prognosis of the two groups before and after blood transfusion were compared. Result:The NK cells,B cells,CD3^(+)T cells,CD4^(+)T cells and CD4^(+)/CD8^(+) ratios were significantly lower in the observation group and the control group(P<0.01).7 d after the transfusion they gradually increased,and the comparison between the observation group and the pre-transfusion group was statistically significant(P<0.01),while the comparison between the control group and the pre-transfusion group was not statistically significant(P>0.05).The comparison of CD8^(+)T cells before and after blood transfusion was not statistically significant(P>0.05).There was no significant difference between the two groups(P>0.05).The ratios of NK cells,B cells,CD3^(+)T cells,CD4^(+)T cells and CD4^(+)/CD8^(+) on 1 d and 7 d after transfusion were significantly lower in the observation group than those in the control group(P<0.05).There was no difference in CD8^(+)T cells(P>0.05).The postoperative infection rate and 2-year recurrence rate were statistically significant in the observation group and the control group(χ^(2)=5.075,P<0.05,χ^(2)=9.87,P<0.01).Conclusion:RhE antigen mismatched infusion could significantly reduce perioperative immune function and poor recovery in patients with RhE-negative ovarian cancer,and increase the postoperative infection rate and 2-year recurrence rate.
作者
胡婷婷
孙婷
李凌波
HU Tingting;SUN Ting;LI Lingbo(Cancer Hospital of China University,Liaoning Cancer Hospital&Institute,Shenyang,110042,China;Changchun Biotechnology Limited Company)
出处
《临床血液学杂志（输血与检验）》
CAS
2020年第6期817-820,共4页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
基金
吉林省科技发展计划项目(No:20150307011YY)。
关键词
RhE抗原
卵巢癌
免疫功能
预后
RhE antigen
ovarian cancer
immune function
prognostic
