摘要
目的探讨RH血型E抗原在输血中对受血者机体免疫功能的影响。方法选取收治入本院需输血治疗的患者,筛选交叉配血相合、不规则抗体筛查阴性的受血者共98例进行研究,以49例受血者E抗原阴性、供血者E抗原阳性为观察组;以49例受血者E抗原阴性、供血者E抗原阴性者为对照组;采用ELISA法对两组患者输血前后血清免疫球蛋白M(Ig M)抗体、白细胞介素-2(IL-2)表达情况进行测定。结果对照组患者输血前后Ig M抗体、IL-2抗体比较差异无统计学意义(P>0.05);观察组患者输血后第3天、第5天Ig M抗体与输血前比较差异有统计学意义(P<0.05);输血后第10天开始下降,至第18天降至输血前水平;且观察组患者输血后第3天与输血前IL-2比较差异有统计学意义(P<0.05)。结论 E抗原阴性患者输注E抗原阳性红细胞后Ig M抗体、IL-2表达情况均会出现上升现象,随着时间的延长逐渐恢复至输血前水平。
Objective To investigate the effects of RH blood group E antigen on the immune function of blood transfusion recipients. Methods A total of 98 patients who received blood transfusion therapy and screened for cross-matching and irregular antibody screening were selected for the study. 49 patients with E antigen-negative and blood donor E antigen positive were used as observed group; 49 patients with E antigen negative and donor E antigen negative were used as control group. The expression of serum immunoglobulin M（Ig M）antibody and interleukin-2（IL-2） was measured by ELISA before and after transfusion. Results There was no significant difference in Ig M antibody and IL-2 levels between the control group before and after transfusion（P〉0.05）. There was significant difference between Ig M antibodies levels in the observation group after 3 d and 5 d transfusion and before transfusion（P〈0.05）. After the 10 d, the Ig M antibodies level began to decline,and it decreased to the level of before transfusion at 18 d. The IL-2 level at the 3 d after transfusion and before transfusion was statistically significant（P〈0.05）. Conclusion The expression of Ig M antibody and IL-2 increased in E antigen-negative patients after infusion of E antigen-positive red blood cells, and gradually returned to the pre-transfusion level with the prolongation of time.
作者
王容
WANG Rong(People＇s Hospital of Changjiang,Changjiang,Hainan 572700,China)
出处
《热带医学杂志》
CAS
2018年第8期1108-1110,1127,共4页
Journal of Tropical Medicine
关键词
RH血型
E抗原
免疫功能
RH blood group
E antigen
Immune function
