摘要
目的探讨血管内皮生长因子(VEGF)基因936C/T多态性与急性心肌梗死(AMI)发病的关系。方法选取AMI患者165例(AMI组)和同期门诊体检健康者105例(CON组),比较两组VEGF基因936C/T多态性及一般临床资料的差异,分析VEGF基因936C/T多态性与AMI发病的关系。结果AMI组VEGF、年龄、TC、LDL及高血压比例均高于CON组(P均<0.05)。两组VEGF基因936C/T多态性分布和等位基因频率差异有统计学意义(P均<0.05):AMI组CC基因型患者比例和C等位基因频率低于CON组(P均<0.05)。与CT和TT基因型患者相比,CC基因型患者的VEGF水平较高,肌酸激酶同工酶(CK-MB)和肌钙蛋白I(CTnI)水平较低(P均<0.05);CT和TT基因型患者的VEGF、CK-MB、CtnI水平比较差异均无统计学意义(P均>0.05)。多因素Logistic回归分析显示,年龄(OR=1.881)、TC(OR=1.692)、高血压(OR=3.527)、CT(OR=2.759)及TT(OR=3.875)基因型均是AMI的独立危险因素(P均<0.05)。结论VEGF基因936C/T多态性与AMI发病关系密切,其中T等位基因是AMI的易感基因。
Objective To investigate the relationship between 936C/T polymorphisms of vascular endothelial growth factor(VEGF)gene and the morbidity of acute myocardial infarction(AMI).Methods A total of 165 patients with AMI(AMI group)and 105 healthy patients who underwent outpatient physical examination during the same period(CON group)were selected.The differences of 936C/T polymorphisms of VEGF gene and general clinical data between the two groups were compared,and the relationship between 936C/T polymorphisms of VEGF gene and the morbidity of AMI was analyzed.Results The levels of VEGF,age,total cholesterol(TC),low-density lipoprotein(LDL)and hypertension in the AMI group were significantly higher than those in the CON group(all P<0.05).The distribution of 936C/T polymorphisms and allele frequency of VEGF gene were significantly different between the two groups:the proportion of patients with CC genotype and C allele frequency in the AMI group were significantly lower than those in the CON group(all P<0.05).Compared with patients with CT and TT genotypes,patients with CC genotype had higher levels of VEGF and lower levels of creatine kinase isoenzyme(CK-MB)and troponin I(CTnI)(all P<0.05).There was no significant difference in VEGF,CK-MB or CTnI levels between patients with CT and TT genotypes(all P>0.05).Logistic multivariate regression analysis showed that age(OR=1.881),TC(OR=1.692),hypertension(OR=3.527),CT(OR=2.759)and TT(OR=3.875)genotypes were all independent risk factors for AMI(all P<0.05).Conclusion The 936C/T polymorphisms of VEGF gene is closely related to the morbidity of AMI,and the T allele is the susceptible allele of AMI.
作者
韩晶晶
马莉
王小文
HAN Jingjing;MA Li;WANG Xiaowen(The First People's Hospital of Lanzhou City,Lanzhou 730050,China)
出处
《山东医药》
CAS
2021年第7期6-9,共4页
Shandong Medical Journal
基金
甘肃省卫生行业科研计划项目(GSWSKY2017-121)。
关键词
急性心肌梗死
血管内皮生长因子
基因多态性
危险因素
acute myocardial infarction
vascular endothelial growth factor
gene polymorphisms
risk factors
