摘要
脓毒症的早期诊断与治疗一直是儿科危重症的焦点问题。近年世界卫生组织(WHO)提出了“预防、诊断和临床处理一体化干预”的理念,我国急诊领域一批权威专家也率先提出了“预防脓毒症行动”(PSCC),但如何在临床工作中有效协调处理好相关问题,尤其是如何做到早期精准诊断并为后期采取集束化策略精准救治还是需要积极关注的热点问题。本文综述了儿童脓毒症的生物标志物、多维评分方法及具有诊断意义的生理参数与变量、机器脓毒症预测系统等诊断手段的最新研究及相关进展,以期将来为儿童脓毒症的早期诊断及精准治疗提供参考,为临床医生提供帮助。
The early diagnosis and treatment of sepsis has always been the focus of pediatric critical illness.In recent years,the World Health Organization(WHO)bring forth the concept of“integrated intervention of prevention,diagnosis and clinical treatment”.A group of authoritative experts in the field of emergency treatment in China have also taken the lead in projecting the“prevention of sepsis campaign in China”(PSCC),but how to effectively coordinate and deal with relevant issues in clinical work,especially how to make early accurate diagnosis and take bundle strategy of intensive treatment for the later stage is still a hot issue that needs active attention.In this paper,some new reaearch and related progress of the diagnostic methods of children sepsis,such as biomarkers,multi-dimensional scoring methods,physiological parameters and variables of diagnostic significance,and the prediction system of mechanical sepsis are reviewed in order to provide reference for early diagnosis and accurate treatment of children sepsis in the future,and to offer assistance for clinicians.
作者
林小飞
顾小海
于春琳
朱红利
吴云朵
张军
王玉美
LIN Xiaofei;GU Xiaohai;YU Chunlin;ZHU Hongli;WU Yunduo;ZHANG Jun;WANG Yumei(Department of Pediatrics,the Huai’an Maternity and Child Clinical College of Xuzhou Medical University,Jiangsu Province,Huai’an223002,China;Neonatal Disease Screening Center,the Huai’an Maternity and Child Clinical College of Xuzhou Medical University,Jiangsu Province,Huai’an223002,China)
出处
《中国医药导报》
CAS
2021年第4期45-48,60,共5页
China Medical Herald
基金
江苏省妇幼健康科研项目(F201940)
江苏省卫生健康委员会高层次人才“六个一工程”拔尖人才科研项目(LGY2018044)
江苏省淮安市科学技术局科研立项项目(HAB201825)。
关键词
儿童
脓毒症
诊断
进展
Children
Sepsis
Diagnosis
Progress
