摘要
目的探讨脓毒症儿童葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症及非G-6-PD缺乏症患儿炎症因子水平变化情况。方法选取2014年5月-2016年5月广西壮族自治区妇幼保健院接诊的脓毒症儿童G-6-PD缺乏症50例为观察组(多器官功能障碍35例,多器官功能衰竭15例);选择同期在广西壮族自治区妇幼保健院接受治疗的50例脓毒症非G-6-PD缺乏症患儿为对照组。分别采集所有患儿3ml空腹静脉血,检测血清炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)、C反应蛋白(CRP)]水平变化。采用ROC曲线分析各项指标对脓毒症儿童G-6-PD缺乏症恶化的预测价值。结果对照组和观察组血清IL-6分别为(7.35±1.37)pg/ml、(60.21±13.27)pg/ml,IL-8分别为(20.07±3.20)pg/ml、(61.24±6.83)pg/ml,IL-1β分别为(4.02±0.57)pg/ml、(8.15±3.57)pg/ml,CRP分别为(1.83±0.34)mg/L、(13.47±6.35)mg/L,对照组上述炎症因子水平均低于观察组,差异有统计学意义(P<0.05);多器官功能障碍组血清IL-6、IL-8、IL-1β、CRP水平均明显低于多器官功能衰竭组,差异有统计学意义(P<0.05);IL-6、IL-8、IL-1β、CRP对脓毒症儿童G-6-PD缺乏症恶化具有显著的预测价值。结论脓毒症非G-6-PD缺乏症患儿各炎症因子水平明显低于脓毒症儿童G-6-PD缺乏症;血清炎症因子可能参与了脓毒症G-6-PD缺乏症的发生与发展,检测血清炎症因子水平对脓毒症G-6-PD缺乏症的早期鉴别、诊断和预后判断具有极其重要的意义。
Objective To explore the changes of inflammatory factors levels in sepsis children with glucose-6-phosphatedehydrogenase ( G-6-PD) deficiency and without G-6-PD deficiency.Methods Fifty sepsis children with G-6-PD deficiency were selected from Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region from May 2014 to May 2016 as observation group,including 35 children with multiple organ dysfunction syndrome and 15 children with multiple organ failure.Fifty sepsis children without G-6-PD deficiency were selected from the hospital as control group.Fasting venous blood samples ( 3 ml) were obtained,serum inflammatory factors [interleukin- 6 ( IL-6) ,interleukin-8 ( IL-8) ,interleukin-1β ( IL-1β) ,C-reactive protein ( CRP) ]were detected.ROC curve was used to analyze the predictive value of inflammatory indexes for aggravation of G-6-PD deficiency in sepsis children.Results In control group and observation group,the levels of serum IL-6 were ( 7.35±1.37) pg /ml and ( 60.21±13.27) pg /ml,respectively,the levels of serum IL-8 were ( 20.07± 3.20) pg /ml and ( 61.24± 6.83) pg /ml,respectively,the levels of serum IL- 1β were ( 4.02± 0.57) pg /ml and ( 8.15±3.57) pg /ml,respectively,the levels of serum CRP were ( 1.83±0.34) mg /L and ( 13.47±6.35) mg /L,respectively.The levels of serum IL-6,IL-8,IL-1β,and CRP in control group were statistically significantly lower than those in observation group ( P<0.05) .The levels of serum IL-6,IL-8,IL-1β,and CRP in multiple organ dysfunction syndrome group were statistically significantly lower than those in multiple organ failure group ( P<0.05) .IL-6,IL-8,IL-1β,and CRP had significant predictive value for aggravation of G-6- PD deficiency in sepsis children.Conclusion The levels of inflammatory factors in sepsis children without G-6-PD deficiency are significantly lower than those in sepsis children with G-6-PD deficiency.Serum inflammatory factors may be involved in the occurrence and development of G-6-PD deficiency in sepsis children.The detection
作者
唐育鹏
莫武桂
黄维真
李卓
韦蓉
TANG Yu-Peng;MO Wu-Gui;HUANG Wei-Zhen(Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530002,China)
出处
《中国妇幼保健》
CAS
2018年第23期5446-5449,共4页
Maternal and Child Health Care of China
基金
广西医疗卫生适宜技术与开发课题(S201405-04)
