摘要
目的探讨骨力胶囊联合鲑鱼降钙素注射液治疗老年骨质疏松症的效果及对骨代谢指标的影响。方法选择2017年1月—2019年1月江苏省新沂市人民医院收治的骨质疏松症老年患者80例,依照随机数字表法分为对照组和观察组,每组40例。对照组采用鲑鱼降钙素注射液,观察组给予骨力胶囊联合鲑鱼降钙素注射液治疗,两组均连续治疗2个月。治疗后进行临床疗效评价。比较两组治疗前后视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、血清骨钙素(BGP)、β-胶原羧基端肽(β-CTX)、25-羟基维生素D_(3)[25-(OH)D_(3)]水平及骨密度、骨矿水平。记录并比较两组治疗过程中不良反应的发生情况。结果观察组的临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后VAS、ODI评分和血清β-CTX水平均明显低于治疗前(P<0.05),血清BGP、25-(OH)D_(3)水平和骨密度、骨矿水平均明显高于治疗前(P<0.05),同时观察组治疗后VAS、ODI评分和血清β-CTX水平均明显小于对照组(P<0.05),观察组治疗后血清BGP、25-(OH)D_(3)水平和骨密度、骨矿水平均明显高于对照组(P<0.05)。治疗期间,两组均无严重的不良反应发生。结论骨力胶囊联合鲑鱼降钙素注射液治疗老年骨质疏松症的临床效果显著,能够明显减轻疼痛,改善骨代谢指标和骨强度,且安全性较好。
Objective To explore the efficacy of Guli Capsules combined with Salmon Calcitonin Injection in treatment of senile osteoporosis and its effects on bone metabolic index.Methods A total of 80 cases of elderly patients with osteoporosis in Xinyi People’s Hospital from January 2017 to January 2019 were selected,according to the random number table method,they were divided into control group and the observation group,40 cases in each group.The control group was treated with Salmon Calcitonin Injection,while the observation group was treated with Guli Capsules combined with Salmon Calcitonin Injection,the two groups were treated for two months.Clinical curative effect was evaluated after treatment.The visual analogue scale(VAS)scores,Oswestry dability index(ODI)scores,serum osteocalcin(BGP),β-collagen carboxy-terminal peptide(β-CTX),25-hydroxyvitamin D_(3)[25-(OH)D_(3)],bone mineral density,bone mineral levels of the two groups before and after treatment were compared.The adverse reactions of the two groups during the treatment were recorded and compared.Results The total effective rate of observation group was significantly higher than that of the control group,the difference between the two groups was statistically significant(P<0.05).After treatment,the VAS,ODI scores and serumβ-CTX of the two groups were significantly lower than before treatment(P<0.05),the BGP,25-(OH)D_(3),bone mineral density and bone mineral levels were significantly higher than before treatment(P<0.05).After treatment,the VAS,ODI score and serumβ-CTX level in the observation group were significantly lower than those in the control group(P<0.05),while the BGP,25-(OH)D_(3) level,bone mineral density and bone mineral level in the observation group were significantly higher than those in the control group(P<0.05).During treatment,there was no serious adverse reaction of the two groups.Conclusion Guli Capsules combined with Salmon Calcitonin Injection has a significant clinical effect in treatment of senile osteoporosis,which can significantl
作者
张伟
刘兆力
汤波
高峰
李恩
ZHANG Wei;LIU Zhaoli;TANG Bo;GAO Feng;LI En(Department of Orthopedic,Xinyi People’s Hospital,Jiangsu Province,Xinyi 221400,China)
出处
《中国医药导报》
CAS
2021年第6期107-110,共4页
China Medical Herald
基金
江苏省自然科学基金资助项目(BK2016209)。
