摘要
目的探究急性脑梗死(ACI)患者磁共振成象(MRI)表现与炎症、凝血及血管新生因子的关系。方法选择2018年12月至2020年3月上海市静安区中心医院收治的158例ACI患者为研究对象,通过MRI弥散加权成像测定所有患者脑梗死面积,根据脑梗面积划分为大面积组65例和小面积组93例。另选取同期体检无脑梗患者50例作为对照组。检测并比较三组受检者的炎症、凝血及血管新生因子水平,并通过Person检验法将以上指标与患者的梗死面积进行相关性分析。结果与对照组比较,大面积组及小面积组患者的C反应蛋白(CRP)、白细胞介素-6 (IL-6)、白细胞计数、中性粒细胞、D二聚体(DD)、纤维蛋白原(FIB)及基质金属蛋白酶(MMP-9)、血管内皮生长因子(VEGF)水平明显升高,而活性部分凝血酶原时间(APTT)、凝血酶原时间(PT)水平明显降低,差异均有统计学意义(P<0.05);与小面积组比较,大面积组患者的CRP、IL-6、白细胞计数、中性粒细胞、DD、FIB、MMP-9、VEGF水平明显升高,而APTT、PT水平明显降低,差异均有统计学意义(P<0.05);脑梗死面积与CRP、IL-6、白细胞计数、中性粒细胞、DD、FIB、MMP-9、VEGF水平均呈正相关(P<0.05),而与APTT、PT均呈负相关(P<0.05)。结论 MRI弥散加权成像技术检测ACI患者的梗死面积与其血清中炎症因子、凝血指标及血管新生因子水平存在显著相关。
Objective To explore the relationship between magnetic resonance imaging(MRI)performances and inflammation,coagulation and angiogenesis factors in patients with acute cerebral infarction.Methods A total of 158 patients with acute cerebral infarction admitted to Shanghai Jing'an District Central Hospital from December 2018 to March 2020 were selected as the study subjects.The cerebral infarction area of all the patients was measured by MRI diffused weighted imaging.According to the cerebral infarction area,the patients were divided into large area group(n=65)and small area group(n=93).In addition,50 patients without cerebral infarction during physical examination were selected as the control group.The levels of inflammation,coagulation and angiogenesis factors were detected and compared among the subjects in the 3 groups,and the correlation between the above indicators and the infarction area of the patients was analyzed by the Pearson chi-squared test.Results Compared with the control group,the levels of C reactive protein(CRP),interleukin 6(IL-6),white blood cell count,neutrophils,D dimer(DD),fibrinogen(FIB),and matrix metalloproteinases(MMP-9),vascular endothelial growth factor(VEGF)increased significantly in large area group and small area group,and the activity of prothrombin time(APTT),prothrombin time(PT)were significantly reduced in large area group and small area group(P<0.05);compared with the small area group,the levels of CRP,IL-6,WBC count,neutrophil,DD,FIB,MMP-9,and VEGF in the large area group were significantly increased,while the levels of APTT and PT were significantly decreased(P<0.05).Cerebral infarction area was positively correlated with CRP,IL-6,WBC count,neutrophil,DD,FIB,MMP-9,and VEGF levels(P<0.05),while negatively correlated with APTT and PT(P<0.05).Conclusion The infarct size of ACI patients detected by diffusion-weighted MRI is correlated to the inflammatory factors,coagulation indexes,and angiogenic factors.
作者
林婷庭
司徒炜宸
LIN Ting-ting;SITU Wei-chen(Department of Radiology,Shanghai Jing'an District Central Hospital,Shanghai 200040,CHINA)
出处
《海南医学》
CAS
2021年第4期430-433,共4页
Hainan Medical Journal
关键词
急性脑梗死
磁共振成像
炎症
凝血
血管新生因子
相关性
Acute cerebral infarction
Magnetic resonance imaging
Inflammation
Blood coagulation
Angiogenesis factor
Relevance
