摘要
目的探究同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)联合凝血功能检测与急性脑梗死患者病情严重程度的相关性及诊断价值。方法选择88例急性脑梗死患者作为此次研究的观察组,并选取同期入院进行健康体检的80例患者作为对照组,对两组患者的Hcy、hs-CRP、凝血功能[纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)]进行检测,比较两组的上述指标,并根据患者入院时美国国立卫生院卒中量表(NIHSS)对急性脑梗死患者的病情严重程度进行评估,将88例急性脑梗死患者分为轻度组、中度组、重度组,对三组不同病情程度患者的Hcy、hs-CRP、FIB、PT、TT、APTT水平进行检测,并采用Pearson相关性分析对患者的病情严重程度与Hcy、hs-CRP、凝血功能指标的相关性进行评估,同时分析各指标单一、联合检测对不同病情严重程度的诊断效能。结果观察组的Hcy、hs-CRP、FIB水平均高于对照组,PT、TT、APTT水平均低于对照组(P<0.05);经NIHSS评估,轻度组有29例,中度组有35例,重度组有24例。在不同病情严重程度患者中,重度组的Hcy、hs-CRP、FIB水平均高于轻度组、中度组,PT、TT、APTT水平均低于轻度组、中度组(P<0.05),中度组上述各项指标与轻度组也存在明显差异(P<0.05)。经Pearson相关性分析发现,急性脑梗死患者的病情严重程度与Hcy、hs-CRP、FIB呈正相关,与PT、TT、APTT呈负相关(P<0.05)。经ROC曲线分析,发现各指标联合检测对不同病情严重程度急性脑梗死患者的敏感度、特异度均高于单一检测(P<0.05)。结论Hcy、hs-CRP联合凝血功能检测可对急性脑梗死患者的病情严重程度进行有效评估。
Objective To investigate the correlation and diagnostic value of homocysteine(Hcy)and ultrasensitive C-reactive protein(hs-CRP)combined with coagulation test and the severity of acute cerebral infarction patients.Methods Eighty-eight patients with acute cerebral infarction were selected as the observation group of this study,and 80 patients who were admitted to the hospital for health examination at the same time were selected as the control group of this study.Hcy,hs-CRP,coagulation function[fibrinogen(FIB),prothrombin time(PT),thromboplastin time(TT),activated partial thromboplastin time(APTT)]were tested in both groups.The above indexes were compared between the two groups,and the severity of acute cerebral infarction patients was assessed according to the NIH SS at the time of patient admission.88 patients with acute cerebral infarction were divided into mild,moderate and severe groups,and the levels of Hcy,hs-CRP,FIB,PT,TT and APTT were tested in the three groups with different degrees of disease,and the levels of Hcy,hsCRP,FIB,PT,TT and APTT were measured using Pearson correlation analysis was used to evaluate the correlation between the severity of patients'disease and Hcy,hs-CRP and coagulation indexes,and the diagnostic efficacy of single and combined tests of each index on different severity of disease was also analyzed.Results In the observation group,the levels of Hcy,hs-CRP,and FIB were higher than those in the control group,and the levels of PT,TT,and APTT were lower than those in the control group(P<0.05);there were 29 cases in the mild group,35 cases in the moderate group,and 24 cases in the severe group as assessed by NIHSS.Among patients with different severity of disease,the levels of Hcy,hs-CRP,and FIB in the severe group were higher than those in the mild and moderate groups,and the levels of PT,TT,and APTT were lower than those in the mild and moderate groups(P<0.05),and there were also significant differences between the above indices in the moderate group and the mild group(P<0.05).By Pear
作者
程丽丽
唐彩云
谌保娣
Cheng Lili;Tang Caiyun;Chen Baodi(Xiangshui County Traditional Chinese Medicine Hospital,Yancheng,Jiangsu 224600,China)
出处
《首都食品与医药》
2023年第20期88-91,共4页
Capital Food Medicine
关键词
同型半胱氨酸
超敏C反应蛋白
凝血功能
急性脑梗死
病情严重程度
Homocysteine
ultrasensitive C-reactive protein
coagulation
acute cerebral infarction
severity of illness
