摘要
目的探讨丹红注射液辅助米力农注射液治疗慢性肺心病呼吸衰竭患者的临床效果及安全性。方法前瞻性选取2017年3月至2019年5月四川省人民医院诊治的120例慢性肺心病呼吸衰竭患者,采用随机数字表法分为研究组和对照组,各60例。2组患者均给予米力农注射液等基础药物治疗、同时给予无创正压通气治疗,研究组患者同时给予丹红注射液治疗。比较2组患者的临床疗效。比较2组患者治疗前、治疗2周后的血气指标、血清一氧化氮(NO)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、血小板聚集率。比较2组患者不良反应发生情况。结果治疗2周后,研究组患者的临床效果(显效70.00%、有效28.33%、无效1.67%)优于对照组(显效51.67%、有效43.33%、无效5.00%),差异有统计学意义(P<0.05)。治疗前,2组患者的PaO2、PaCO2、pH值、SaO2测定值差异无统计学意义(P>0.05);治疗2周后,研究组患者的PaO 2、pH值、SaO 2测定值为(85.3±7.4)mmHg、7.36±0.06、(94.2±3.0)%,显著高于对照组[(81.0±7.2)mmHg、7.33±0.05、(91.0±3.6)%],PaCO 2测定值[(38.9±4.8)mmHg]显著低于对照组[(42.4±5.2)mmHg],差异有统计学意义(P<0.05)。治疗前,2组患者的NO、hs-CRP、TNF-α、ET-1、血小板聚集率测定值差异无统计学意义(P>0.05);治疗2周后,研究组患者的NO测定值[(57.2±5.8)μmol/L]高于对照组[(52.8±6.1)μmol/L],hs-CRP、TNF-α、ET-1、血小板聚集测定值为(3.2±1.1)mg/L、(38.2±11.0)pg/mL、(48.3±9.0)ng/L、(34.8±5.1)%,显著低于对照组[(4.5±1.4)mg/L、(44.1±13.2)pg/mL、(57.0±10.0)ng/L、(39.5±7.3)%],差异有统计学意义(P<0.05)。2组不良反应发生率比较(5.0%vs.11.7%),差异无统计学意义(P>0.05)。结论丹红注射液辅助米力农注射液治疗慢性肺心病呼吸衰竭患者能显著的改善患者血气水平、降低炎性反应及血小板聚集率,从而提高临床效果,同时安全性高。
Objective To explore the clinical effect and safety of Danhong injection assisted milrinone injection in the treatment of patients with chronic pulmonary heart disease with respiratory failure.Methods 120 patients with chronic pulmonary heart disease respiratory failure who were diagnosed and treated in Sichuan Provincial People's Hospital from March 2017 to May 2019 were randomly divided into study group and control group.The two groups were given milrinone injection and other basic drugs.The patients in the study group were treated with Danhong injection at the same time.The blood gas indexes,serum nitric oxide(NO)and high-sensitivity C-reactive protein(hs-CRP)were compared before treatment,after 2 weeks treatment.Tumor necrosis factorα(TNF-α),endothelin-1(ET-1).The clinical efficacy and adverse reactions of the two groups were compared.Results After 2 weeks treatment,the clinical effect of the study group(markedly effective 70.00%,effective 28.33%,ineffective 1.67%)was better than that of the control group(markedly effective 51.67%,effective 43.33%,ineffective 5.00%),and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the measured values of PaO 2,pH and SaO 2 in the study group were(85.3±7.4)mmHg,7.36±0.06,(94.2±3.0)%,which were significantly higher than those in the control group[(81.0±7.2)mmHg,7.33±0.05,(91.0±3.6)%],the measured value of PaCO 2[(38.9±4.8)mmHg]was significantly lower than the control group[(42.4±5.2)mmHg],the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the measured values of NO,hs-CRP,TNF-α,ET-1,and platelet aggregation rate between the two groups(P>0.05);after 2 weeks of treatment,the measured values of NO in the study group[(57.2±5.8)μmol/L]was higher than the control group[(52.8±6.1)μmol/L],the measured values of hs-CRP,TNF-α,ET-1,platelet aggregation were(3.2±1.1)mg/L,(38.2±11.0)pg/mL,(48.3±9.0)ng/L,(34.8±5.1)%,which were significantly lower than the control group[(4.5±1.4)mg/
作者
敬仁芝
郭文利
章晓红
吴海燕
饶利
JING Ren-zhi;GUO Wen-li;ZHANG Xiao-hong(Department of Geriatric Intensive Care,Sichuan Provincial People's Hospital,Chengdu Sichuan 610072,China;Chengdu Hospital of Integrated Traditional Chinese and Western Medicine,Chengdu Sichuan 610041,China.;Department of Emergency Medicine,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,Chengdu Sichuan 610072,China)
出处
《临床和实验医学杂志》
2021年第3期270-273,共4页
Journal of Clinical and Experimental Medicine
基金
四川省卫健委干部保健科研课题(编号:川干研2017-226)。
关键词
慢性肺心病
丹红注射液
米力农注射液
呼吸衰竭
安全性
Chronic pulmonary heart disease
Danhong injection
Milrinone injection
Respiratory failure
Safety
