摘要
目的:探讨前列腺癌(PCa)患者肿瘤标志物及相关细胞因子的表达水平及其临床意义。方法:选取在医院泌尿外科行PCa筛查的77例PCa患者,将其纳入观察组,另选同期健康体检的30名男性为健康对照组,分别测定两组总前列腺特异性抗原(tPSA)、游离前列腺特异性抗原(fPSA)、游离前列腺特异性抗原与总前列腺特异性抗原比值(fPSA/tPSA)、白细胞介素6(IL-6)、白细胞介素17A(IL-17A)和肿瘤坏死因子(TNF-ɑ)的水平。对比两组肿瘤标志物及相关细胞因子的表达水平,分析tPSA和fPSA水平与Gleason分级和骨转移的相关性。结果:观察组的tPSA、fPSA、IL-6、TNF-ɑ及IL-17A均显著高于健康对照组,差异有统计学意义(U=6.514,U=6.303,U=4.363,U=3.327,U=3.077;P<0.05);fPSA/tPSA明显低于健康对照组,差异有统计学意义(U=5.380,P<0.05)。Gleason分级评分高危患者的tPSA、fPSA高于低危患者,差异有统计学意义(U=2.834,U=3.345;P<0.05)。骨转移患者的tPSA、fPSA高于非转移患者,差异有统计学意义(U=3.629,U=3.607;P<0.05)。结论:前列腺癌患者外周血中tPSA、fPSA、IL-6、TNF-ɑ及IL-17A的水平明显升高。tPSA和fPSA水平与Gleason分级和骨转移呈正相关,可反应疾病严重程度。
Objective:To investigate the expression and clinical significance of the tumor markers and the related cytokines in patients with prostate cancer(PCa).Methods:77 patients with PCa who underwent PCa screening in the urology department were divided into the observation group,and another 30 healthy males who underwent health physical examination were selected as the health control group.The total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),the ratio of free prostate specific antigen to total prostate specific antigen(fPSA/tPSA),interleukin-6(IL-6),interleukin-17A(IL-17A)and tumor necrosis factor(TNF-ɑ)of two groups were measured.The expression levels of tumor markers and related cytokines between the two groups were compared,and the correlation of tPSA and fPSA levels with Gleason grading and bone metastasis were further analyzed.Results:tPSA,fPSA,IL-6,TNF-ɑand IL-17A in observation group were significantly higher than those in healthy control group(U=6.514,U=6.303,U=4.303,U=3.327,U=3.077,P<0.05).The fPSA/tPSA of observation group was significantly lower than that of healthy control group(U=5.380,P<0.05).The level of tPSA and fPSA of high-risk group of Gleason grading score were significantly higher than those of low-risk group(U=2.834,U=3.345,P<0.05).The tPSA and fPSA in bone metastasis group were significantly higher than those in non-metastasis group(U=3.629,U=3.607,P<0.05).Conclusion:The levels of tPSA,fPSA,IL-6,TNF-ɑand IL-17A in peripheral blood of patients with PCa are significantly increased.The levels of tPSA and fPSA are positively correlated with GLeason grading and bone metastasis,which can reflect the severity of the disease.
作者
毛镭篥
吴卫
黄媛
张丽
李薇
崔巍
MAO Lei-li;WU Wei;HUANG Yuan(Department of Clinical Laboratory,Chinese Academy of Medical Science&Peking Union Medical College Hospital,Beijing 100730,China;不详)
出处
《中国医学装备》
2021年第2期77-81,共5页
China Medical Equipment
基金
北京市临床重点专科医学检验科卓越项目(ZK201000)
中国医学科学院医学与健康科技创新工程(2017-12M-3-005)协同创新团队项目“循环多肽组在恶性肿瘤预后检测中的临床应用研究”。
