摘要
慢性乙型肝炎患者肝脏损害多发生在免疫介导作用下,考虑病毒感染和免疫反应的相互作用是疾病病情进展的重要原因。慢性乙型肝炎可发展至肝纤维化、肝硬化甚至肝细胞癌。回顾了辅助性T淋巴细胞17(Th17)与调节性T淋巴细胞(Treg)的发现起源,叙述了二者自身特性,同时阐述了在维持免疫系统稳定过程中二者所起的作用及作用机制;详细分析了细胞失衡在慢性乙型肝炎、肝纤维化、肝硬化、肝细胞癌等各个阶段中的作用,指出Th17/Treg失衡会促使HBV相关肝脏疾病病情加重。
Patients with chronic hepatitis B(CHB)often have immune-mediated liver injury,and it is considered that the interaction between viral infection and immune response is an important cause of disease progression.CHB can progress to liver fibrosis,liver cirrhosis,and even hepatocellular carcinoma(HCC).This article reviews the discovery of T helper 17(Th17)cells and regulatory T(Treg)cells,describes their own features,and elaborates on their role and mechanism of action in maintaining the stability of the immune system.This article also analyzes the role of Th17/Treg cell imbalance in CHB,liver fibrosis,liver cirrhosis,and HCC and points out that Th17/Treg cell imbalance may promote the aggravation of HBV-related liver diseases.
作者
唐光俊
游晶
刘怀鄂
彭玉娟
TANG Guangjun;YOU Jing;LIU Huai’e;PENG Yujuan(Department of Infectious Diseases and Hepatology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第2期414-418,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81760111,81760617)
云南省应用基础研究项目(2017FE468〔-033〕)。
