摘要
近年来,应用支架介入治疗良恶性因素引起的非血管管腔狭窄的方法受到国内外研究者的广泛关注,尤其是恶性肿瘤疾病高发,进一步促进了支架介入治疗的发展。传统的裸支架易刺激管腔黏膜产生再狭窄等一系列并发症,药物洗脱支架的出现有望解决这一问题,成为非血管支架的重要发展趋势之一。该文综合近年的研究及应用文献,对非血管药物洗脱支架的载药材料、载药层药物、制备工艺及评价方法等进行了综述,以期为后续的研究和发展提供依据和方向。
In recent years,the application of stent intervention in the treatment of non-vascular stenosis caused by benign and malignant factors has been widely concerned by researchers at home and abroad.The high incidence of malignant tumor diseases,further promotes the development of stent intervention.The conventional bare stents are prone to irritate luminal mucosa and produce restenosis and other complications.The emergence of drug-eluting stent is expected to solve this problem and become one of the important development trends of non-vascular stents.In this paper,the drug loading materials,drug loading layer drugs,preparation technology and quality evaluation methods of non-vascular drugeluting stent are described based on the recent research and clinical application documents,so as to provide basis and direction for the follow-up research and development.
作者
甘瑜
闻聪
金方
朱华
GAN Yu;WEN Cong;JIN Fang;ZHU Hua(Yangzhou University Medical Academy,Yangzhou,225009;Guangzhou Joincare Respiratory Medicine Co.Ltd,Guangzhou,510530;Shanghai Frontier Health Pharmaceutical Technology Co.Ltd,Shanghai,200120;State Key Laboratory of Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou,510120;Jiangsu Subei People's Hospital Affiliated to Medical School,Yangzhou University,Yangzhou,225001)
出处
《中国医疗器械杂志》
2021年第1期46-51,共6页
Chinese Journal of Medical Instrumentation
基金
“重大新药创制”科技重大专项(2017ZX09201002-002)
广东省重点领域研发计划(2019B020204001)
广州创新创业领军人才项目(CY2018-021)。
关键词
介入治疗
非血管
药物洗脱支架
制备及评价
interventional therapy
non-vascular
drug-eluting stent
preparation and evaluation
