摘要
药物洗脱支架是经皮冠状动脉介入治疗的主要器械之一,通过药械组合方式发挥治疗作用。药物作为药物洗脱支架的重要组成部分,其装载方式、载体的种类、药物和载体的相互作用、制备工艺等直接影响器械的药物释放动力学特征及最终治疗效果。依据药物涂层的特性,可将药物洗脱支架分为永久聚合物药物涂层支架、可降解聚合物药物涂层支架以及无载体药物洗脱支架等。该文对上述三类支架涂层工艺及药物释放动力学等进行了论述。
Drug eluting stents are one of the main devices of coronary intervention, which play a therapeutic role through the combination of medical devices. Drug is an important part of the drug eluting stents. The loading method, the type of carrier, drug and carrier interaction and the preparation process of the drug directly affect the drugs release kinetics characteristics of the device and the final treatment. According to the characteristics of the drug coating, drug coated stents can be divided into non-degradable polymers drug coated stents, biodegradable polymers drug coated stents and polymer-free drug eluting stents. This article discussed the stent coating process and drug release kinetics of the three types of drug eluting stent.
作者
宋彩霞
周超
张海军
SONG Caixia;ZHOU Chao;ZHANG Haijun(National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 2511002;School of Material Science and Engineering, University of Science and Technology Beijing , Beijing, 100083;Institute of Vascular Intervention, Medical College of Tongji University, Shanghai, 20007)
出处
《中国医疗器械杂志》
2018年第3期193-197,共5页
Chinese Journal of Medical Instrumentation
基金
国家科技支撑计划(2014BAI11B04)
