摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种临床上常见的神经系统退行性疾病,严重威胁老年人的健康。AD病理机制仍不清楚,尚无特效治疗药物。目前,非药物治疗正逐渐引起人们关注,研究证实,认知干预与运动干预是延缓AD病理症状的有效治疗策略。其中,认知干预能延缓AD患者认知老化速度,提高患者对外界事物的应激反应,而运动干预则能通过减少过量Aβ沉积和Tau蛋白过度磷酸化、改变表观遗传修饰、促进神经营养因子和神经生长因子释放、激活AMPK信号通路、抑制炎症反应等降低或延缓AD发生。该文通过对认知干预与运动干预所产生的疗效和作用机制进行综述,为运动与认知干预的非药物治疗实施提供理论依据。
AD(Alzheimer’s disease)is a clinically common neurodegenerative disorder that seriously threatens the aged people.However,the pathological mechanism of AD is still remain unclear and there are no effective treatment drugs.At present,a promising nonpharmacological therapy is attracting increasing attention.Accumulating evidence suggests that both exercise and cognitive interventions may be cost-effective strategies to ameliorate the pathological symptoms of AD.Cognitive intervention can delay the cognitive decline of AD patients and improve their stress responses to external events,while exercise intervention can reduce or delay the occurrences of AD by reducing excessive Aβdeposition and preventing the formation of hyperphosphorylated Tau protein,altering epigenetic modifications,promoting the release of neurotrophic factors and nerve growth factors,activating AMPK signaling pathway,as well as inhibiting inflammatory responses.This article reviews the curative effect and mechanism of cognitive and exercise interventions,hoping to provide a theoretical basis for the nonpharmacological therapy of those interventions to the AD patients.
作者
李婉怡
高君妍
林苏扬
刘志涛
王钦文
李广宇
李丽萍
LI Wanyi;GAO Junyan;LIN Suyang;LIU Zhitao;WANG Qinwen;LI Guangyu;LI Liping(Faculty of Physical Education Ningbo University,Ningbo 315211,China;Ningbo University School of Medicine,Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo 315211,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第12期2244-2255,共12页
Chinese Journal of Cell Biology
基金
国家自然科学基金/青年科学基金(批准号:82001155)
浙江省自然科学基金/青年基金(批准号:LQ19H090005)
宁波市自然科学基金(批准号:2018A610305)
宁波市科技局/重大项目(批准号:2019B10034)
宁波大学校科研基金项目自然科学类(批准号:XYL20030)
宁波大学大学生科研创新计划(批准号:2020SRIP1925)
宁波大学研究生科研创新基金(2020)
宁波大学王宽诚幸福基金资助的课题。
关键词
阿尔茨海默病
运动干预
认知干预
认知功能
Alzheimer’s disease
exercise intervention
cognitive intervention
cognitive function
