摘要
股骨头坏死(osteonecrosis of femoral head,ONFH)是骨科的常见病之一,它属于一种渐进性疾病,早期如果不及时进行干预,往往会导致股骨头的进行性破坏,最终引起股骨头结构塌陷,严重影响生活质量。目前临床上股骨头坏死的治疗方式主要是根据ARCO分期及患者自身情况而决定。对于晚期患者往往采用髋关节置换术治疗,但由于假体寿命有限以及患者年龄呈现出年轻化趋势,这一治疗方法效果难以令人满意;对于早期患者可以采用保守治疗及保髋的一系列治疗方法,例如药物干预、改善生活方式、髓芯减压、自体骨移植等,但发现临床效果欠佳。随着组织工程和再生医学领域的不断成熟以及骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)所具有的良好特性,使得BMSCs成为当前临床上基础研究的热门种子细胞。研究人员采用BMSCs联合其他治疗手段治疗股骨头坏死已经观察到了一定的疗效,随着有关方面研究的不断发展,在未来,应用BMSCs治疗ONFH有望成为一种令人满意的治疗方式。
Osteonecrosis of the femoral head is one of the common diseases in orthopedics.It is a progressive disease.If it is not intervened in time in the early stage,it will lead to progressive destruction of the femoral head,and eventually result in the collapse of the structure of the femoral head,which is seriously affecting the quality of life.At present,the clinical treatment of osteonecrosis of the femoral head is mainly based on the ARCO stage and the condition of the patients.Hip arthroplasty is often used for advanced patients,but due to the limited life span of the prosthesis and the younger trend of the patient’s age,the effect of this treatment is not satisfactory.For early patients,a series of conservative treatment and hip preservation can be used,such as drug intervention,lifestyle improvement,core decompression,autogenous bone transplantation and so on,but the clinical effect is not satisfactory.With the continuous maturity of tissue engineering and regenerative medicine and the good characteristics of bone marrow mesenchymal stem cells,BMSCs has become a hot seed cell in clinical basic research.Researchers have observed a certain effect of BMSCs combined with other treatments in the treatment of osteonecrosis of the femoral head.With the continuous development of related research,the application of BMSCs in the treatment of ONFHis expected to become a satisfactory treatment in the future.
作者
谢志鸿
彭吾训
XIE Zhihong;PENG Wuxun(Guizhou Medical University,Guiyang 550004,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2021年第1期20-24,共5页
The Journal of Practical Medicine
基金
国家自然科学基金地区科学基金项目(编号:81860387)
国家自然科学基金青年科学基金项目(编号:81902226)
贵州省卫生健康委员会科学技术基金项目(编号:gzwjkj2019-1-134)
贵州省自然科学基金项目(编号:黔科合基础[2020]1Y311)。
关键词
股骨头坏死
骨髓间充质干细胞
组织工程
osteonecrosis of femoral head
bone marrow mesenchymal stem cells
tissue engineering
