摘要
目的:观察泮托拉唑联合生长抑素治疗乙肝肝硬化上消化道出血的临床效果。方法:以2018年1月—12月本院收治的84例乙肝肝硬化上消化道出血患者为观察对象,按不同治疗方案分为对照组和观察组各42例。对照组给予生长抑素治疗,观察组给予泮托拉唑联合生长抑素治疗。比较两组治疗效果。结果:治疗后,观察组输血量、止血时间、住院时间均少于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组超敏C反应蛋白、皮质醇水平比较,差异无统计学意义(P>0.05)。治疗后,观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)低于对照组,白介素-2(IL-2)高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:泮托拉唑联合生长抑素治疗乙肝肝硬化上消化道出血,临床效果显著,且安全性较高,具有较高的临床研究价值。
Objective:To investigate the effect of pantoprazole plus somatostatin in the treatment of upper gastrointestinal hemorrhage in patients with hepatitis B cirrhosis.Methods:84 cases of hepatitis B cirrhosis patients with upper gastrointestinal bleeding from January 2018 to December 2018 were selected as the observation objects.They were divided into control group and observation group according to different treatment schemes,42 cases in each group.The control group was given somatostatin treatment,the observation group was given pantoprazole combined with somatostatin,the therapeutic effect of the two groups was compared.Results:After treatment,the amount of blood transfusion,hemostasis time and hospitalization time in the observation group were less than those in the control group,the difference was statistically significant(P<0.05);the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);before treatment,the level of hypersensitive C-reactive protein and cortisol between the two groups had no statistical significance(P>0.05),after treatment,the observation group was lower than the control group,the difference was statistically significant(P<0.05);after treatment,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)in the observation group were lower than those in the control group,and the interleukin-2(IL-2)in the observation group was higher than that in the control group(P<0.05);the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Pantoprazole combined with somatostatin in the treatment of hepatitis B cirrhosis with upper gastrointestinal bleeding has significant clinical effect,high safety and high clinical research value.
作者
胥俊杰
XU Junjie(Nancheng County People's Hospital,Nancheng Jiangxi 344700,China)
出处
《药品评价》
CAS
2020年第21期46-48,共3页
Drug Evaluation
关键词
泮托拉唑
生长抑素
乙肝肝硬化
上消化道出血
Pantoprazole
Somatostatin
Hepatitis B Cirrhosis
Upper Gastrointestinal Bleeding
