摘要
目的探讨奥曲肽联合泮托拉唑对肝硬化合并上消化道出血患者的治疗效果及安全性。方法选择我院2015年1月至2018年1月收治的80例肝硬化合并上消化道出血患者为研究对象,按随机数表法分为单用组(n=40)与联合组(n=40),单用组实施单用泮托拉唑治疗,联合组实施奥曲肽联合泮托拉唑治疗。比较两组患者的治疗效果及用药安全性。结果治疗1 d后,两组患者PT、APTT、TT均短于治疗前,FIB水平及平均动脉压均高于治疗前,C反应蛋白、降钙素原水平、心率明显低于治疗前,且联合组均优于单用组(P<0.05);联合组患者的止血时间明显短于单用组,止血总有效率显著高于单用组(P<0.05);联合组住院期间再出血发生率低于单用组(P<0.05);两组患者的用药不良反应总发生率比较,无明显差异(P>0.05)。结论对肝硬化合并上消化道出血患者给予奥曲肽联合泮托拉唑治疗的止血效果良好,用药安全性高。
Objective To investigate the efficacy and safety of octreotide combined with pantoprazole in patients with cirrhosis and upper gastrointestinal hemorrhage.Methods A total of 80 patients with cirrhosis and upper gastrointestinal hemorrhage treated in our hospital from January 2015 to January 2018 were selected as the study objects,and the patients were divided into single-use group(n=40)and combination group(n=40)according to random number table method.The single-use group was treated with pantoprazole alone,and the combination group was treated with octreotide combined with pantoprazole.The efficacy and medication safety in the two groups were compared.Results After 1 day of treatment,the levels of PT,APTT,TT in the two groups were shorter than those before treatment,the levels of FIB and mean arterial pressure were higher than those before treatment,the levels of C-reactive protein,procalcitonin and heart rates were significantly lower than those before treatment,and those in the combination group were better than the single-use group(P<0.05);the hemostasis time of the combination group was significantly shorter than that of the single-use group,and the total effective rate of hemostasis was significantly higher than that of the single-use group(P<0.05);the incidence of rebleeding during hospitalization in the combination group was lower than that in the single-use group(P<0.05).There was no significant difference in incidence of adverse medication reactions between the two groups(P>0.05).Conclusion The octreotide combined with pantoprazole on cirrhosis with upper gastrointestinal hemorrhage has good hemostasis effect and high medication safety.
作者
黄伟
HUANG Wei(Traditional Chinese Medicine Hospital of Xixiang County,Hanzhong 723500,China)
出处
《临床医学研究与实践》
2019年第9期45-47,共3页
Clinical Research and Practice
关键词
肝硬化
上消化道出血
奥曲肽
泮托拉唑
cirrhosis
upper gastrointestinal hemorrhage
octreotide
pantoprazole
