摘要
目的探究生长抑素联合泮托拉唑治疗肝硬化合并上消化道出血的治疗效果。方法选取大连市普兰店区第二人民医院内科2017年1月～2018年4月收治的肝硬化合并上消化道出血者共60例,以抽取红黄球方式分组,红球为实验组,黄球为对照组,每组30例。实验组采用生长抑素联合泮托拉唑治疗,对照组采用生长抑素治疗。分别观察两组患者临床治疗效果、止血时间、输血量、住院所需时间、血红蛋白水平、不良反应总出现率。结果实验组止血时间[(23.62±4.92)vs(34.55±6.20)h]、输血量[(243.92±50.33)ml vs(492.39±55.20)ml]、住院所需时间[(7.66±1.09)d vs(17.20±2.09)d]、不良反应总出现率(6.67%vs 30.00%)均低于对照组,差异具有统计学意义(P<0.05)。实验组临床治疗总有效率(86.67%vs 60.00%)、血红蛋白水平[(120.60±15.00)g/L vs (103.01±15.37)g/L]均高于对照组,差异具有统计学意义(P<0.05)。结论与单一用药相比,给予肝硬化合并上消化道出血患者采用生长抑素联合泮托拉唑治疗,不仅利于改善其血红蛋白水平,更利于减少输血量、住院时间、用药不良反应,进而提升治疗效果。
Objective To investigate the therapeutic effect of somatostatin combined with pantoprazole in the treatment of cirrhosis with upper gastrointestinal bleeding.Methods A total of 60 patients with cirrhosis and upper gastrointestinal bleeding admitted to the Department of Internal Medicine of the Second People's Hospital of Pulandian District,Dalian City from January 2017 to April 2018 were selected.The red and yellow balls were grouped,The red ball was the experimental group and the yellow ball was the control group,30 cases in each group.The experimental group was treated with somatostatin and pantoprazole,and the control group was treated with somatostatin.The clinical treatment effect,hemostasis time,blood transfusion volume,time required for hospitalization,hemoglobin level,and total incidence of adverse reactions were observed in the two groups.Results The hemostasis time of the experimental group[(23.62±4.92)vs(34.55±6.20)h],the transfusion volume[(243.92±50.33)ml vs(492.39±55.20)ml],the time required for hospitalization[(7.66±1.09)d vs(17.20±2.09)d],the total incidence of adverse reactions(6.67%vs 30.00%)were lower than the control group,the difference was statistically significant(P<0.05).The total effective rate of clinical treatment(86.67%vs 60.00%)and hemoglobin level[(120.60±15.00)g/L vs(103.01±15.37)g/L]were higher in the experimental group than in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with single drug administration,the combination of somatostatin and pantoprazole in patients with cirrhosis and upper gastrointestinal hemorrhage is not only beneficial to improve the hemoglobin level,but also to reduce the amount of blood transfusion,hospitalization,adverse drug reactions,and thus improve treatment effect.
作者
张宏程
ZHANG Hong-cheng(Department of Internal Medicine,the Second People's Hospital,Pulandian District,Dalian 116222,Liaoning,China)
出处
《医学信息》
2019年第3期153-154,157,共3页
Journal of Medical Information
关键词
生长抑素
泮托拉唑
肝硬化
上消化道出血
Somatostatin
Pantoprazole
Cirrhosis
Upper gastrointestinal bleeding
