摘要
糖尿病肾病(diabetic nephropathy,DN)为高血糖持续状态所致的肾脏损害,病变可使包括肾小球、肾小管肾间质、肾血管等全肾受累。临床上以持续性白蛋白尿和(或)肾小球滤过率进行性下降为主要特征,可进展为终末期肾衰竭。HIF-1α和VEGF是糖尿病肾病发病机制细胞因子通路上的重要成员,对其深入研究在糖尿病肾病的早期预防及诊断方面意义重大。
Diabetic nephropathy(DN) is the kidney damage caused by the persistent hyperglycaemic state, which can affect the whole kidney including the glomerulus, the renal tubular interstitial and the renal vessels.It is clinically characterized by persistent albuminuria and/or a progressive decline in glomerular filtration rate, which may progress to end-stage renal failureHif-1 and VEGF are important members of the cytokine pathways involved in the pathogenesis of diabetic nephropathy, which are of great significance for their further study in the early prevention and diagnosis of diabetic nephropathy.
作者
马楠
刘艳姝
刘文思
张李理
Ma Nan;Liu Yanshu;Liu Wensi;Zhang Lili(The First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China)
出处
《广东化工》
CAS
2020年第23期63-63,70,共2页
Guangdong Chemical Industry
