摘要
目的:探讨重型颅脑损伤患者的凝血指标变化情况对损伤程度及预后的检测价值.方法:选取2014年1月-2019年12月本院收治的重型颅脑损伤患者98例,根据其症状表现将其分为重度组、中度组及轻度组,选取同期来本院行健康检查的健康人群20例作为对照组.比较各组凝血指标变化情况,分析不同损伤程度患者预后差异.结果:重度组损伤后4、12、24 h PT、APTT、PTT水平均高于中度组、轻度组及对照组(P<0.05),中度组损伤后4、12、24 h PT、APTT、PTT水平均高于轻度组与对照组(P<0.05),轻度组损伤后4、12、24 h PT、APTT、PTT水平均高于对照组(P<0.05);重度组损伤后4、12、24、48 h FDP、D-D水平均高于中度组、轻度组及对照组(P<0.05),中度组损伤后4、12、24、48 h FDP、D-D水平均高于轻度组与对照组(P<0.05),轻度组损伤后4、12、24、48 h FDP、D-D水平均高于对照组(P<0.05);重度组损伤后48 h PT、APTT、PTT水平仍高于对照组(P<0.05).三组预后情况比较,差异有统计学意义(字2=4.666,P<0.05).结论:颅脑损伤患者损伤程度越重,凝血功能紊乱情况越明显,预后情况越差,可通过对凝血指标进行监测的方式,对颅脑损伤患者进行预后评估.
Objective:To explore the value of the change of coagulation index in the detection of the degree of injury and prognosis in patients with severe craniocerebral injury.Method:From January 2014 to December 2019,98 patients with severe craniocerebral injury were selected and divided into severe group,moderate group and mild group according to their symptoms.20 healthy people who came to our hospital for health examination during the same period were selected as the control group.The changes of coagulation indexes in each group were compared,the prognoses of patients with different degrees of injury was analyzed.Result:The levels of PT,APTT and PTT in the severe group were higher than those in the moderate group,the mild group and the control group at 4,12 and 24 h after injury(P<0.05).The levels of PT,APTT and PTT in the moderate group at 4,12 and 24 h after injury were higher than those in the mild group and the control group(P<0.05).The levels of FDP and D-D in the severe group at 4,12,24 and 48 h after injury were all higher than those in the moderate group,the mild group and the control group(P<0.05).The levels of FDP and D-D in the moderate group at 4,12,24 and 48 h after injury were all higher than those in the mild group and the control group(P<0.05).The levels of FDP and D-D in the mild group at 4,12,24 and 48 h after injury were all higher than those in the control group(P<0.05).The levels of PT,APTT and PTT in the severe group at 48 h after injury were still higher than those in the control group(P<0.05).There were significant differences in prognosis among three groups(χ~2=4.666,P<0.05).Conclusion:The more severe the degree of brain injury is,the more obvious the disorder of coagulation function is,the worse the prognosis is.The prognosis of patients with brain injury can be evaluated by monitoring the coagulation index.
作者
吴启东
吴宗良
王海洋
张磊
WU Qidong;WU Zongliang;WANG Haiyang;ZHANG Lei(Mingguang People’s Hospital,Mingguang 239400,China;不详)
出处
《中国医学创新》
CAS
2020年第36期118-121,共4页
Medical Innovation of China
关键词
颅脑损伤
凝血指标
损伤程度
预后
损伤时间
Craniocerebral injury
Coagulation index
Injury degree
Prognosis
Injury time
