摘要
目的研究针药结合促醒法对重型颅脑损伤后昏迷患者的临床疗效。方法选取本院收治的重型颅脑损伤后昏迷患者80例,随机分为对照组和观察组,每组40例,对照组采用常规西医治疗,观察组在对照组基础上加用针药结合促醒法,比较2组治疗前后格拉斯哥昏迷评分(GCS)、格拉斯哥预后评分(GOS)、大脑中动脉(MCA)和颈内动脉(ICA)血流速度、脑脊液中5-羟色胺(5-TH)、多巴胺(DA)、去甲肾上腺素(NE)、乙酰胆碱(Ach)含量的变化。结果治疗后,观察组GCS评分和GOS评分均显著高于对照组(P<0.05);2组MCA和ICA血流速度均显著低于治疗前(P<0.05),且观察组降低程度优于对照组(P<0.05);2组脑脊液5-TH含量均降低(P<0.05),DA、NE、Ach含量均升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论针药结合促醒法能改善重型颅脑损伤后昏迷患者脑血流速度和觉醒相关神经递质的释放,有明显促醒作用。
Objective To study the clinical effect of promoting waking method of acupuncture combined with medicine on patients with coma after severe craniocerebral injury.Methods Eighty patients with coma after severe craniocerebral injury in our hospital were randomly divided into control group and observation group with 40 cases in each group.The control group was treated with routine western medicine,while the observation group was treated with acupuncture combined with medicine on the basis of the control group.The Glasgow Coma Scale（GCS）,the Glasgow outcome scale（GOS）,the middle cerebral artery（MCA）and the internal carotid artery（ICA）blood flow velocity,the changes of 5-hydroxytryptamine（5-TH）,dopamine（DA）,norepinephrine（NE）and acetylcholine（Ach）in the two groups before and after treatment were compared.Results After treatment,the GCS and GOS scores in the observation group were significantly higher than those in the control group（P〈0.05）.The blood flow velocities of MCA and ICA in both groups were significantly lower than those before treatment（P〈0.05）,but the degree of decrease in the observation group was better than that in the control group（P〈0.05）.The content of 5-TH in cerebrospinal fluid decreased in both groups（P〈0.05）,but the improvement degree of observation group was better than that of control group（P〈0.05）.Conclusion Promoting waking method of acupuncture combined with medicine can improve cerebral blood flow velocity and release of arousal related neurotransmitters and has a significant wake-up effect in patients with coma after severe craniocerebral injury.
作者
冯文霞
FENG Wenxia(Hospital of Qi County,Hebi City, 458000, Chin)
出处
《中西医结合研究》
2017年第5期225-227,共3页
Research of Integrated Traditional Chinese and Western Medicine
关键词
重型颅脑损伤
昏迷
针药结合促醒法
临床疗效
severe craniocerebral injury
coma
promoting waking method of acupuncture combined with medicine
clinical effect
