摘要
目的研究成人隐匿性自身免疫糖尿病(LADA)患者体内不同25羟维生素D3[25(OH)D3]水平与胰岛细胞自身抗体和炎症指标的关系。方法选取2016年8月至2019年12月该院临床诊断为LADA的患者67例,根据25(OH)D3水平将其分为充足组、不足组、缺乏组,收集各组一般资料,检测胰岛细胞自身抗体、血常规、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)水平。结果缺乏组中性粒细胞计数、CRP水平高于充足组,不足组中性粒细胞计数高于充足组,差异均有统计学意义(P<0.05)。25(OH)D3水平与白细胞计数、中性粒细胞计数、CRP呈明显负相关(P<0.05)。5种胰岛细胞自身抗体阳性率比较:谷氨酸脱羧酶抗体(GADA)>锌转运蛋白8抗体(ZnT-8A)>蛋白酪氨酸磷酸酶自身抗体(IA-2A)>胰岛素自身抗体(IAA)>胰岛细胞抗体(ICA)。3组各胰岛细胞自身抗体阳性率差异无统计学意义(P>0.05)。充足组1种胰岛细胞自身抗体阳性的比例高于缺乏组,≥2种胰岛细胞自身抗体阳性的比例低于缺乏组,差异均有统计学意义(P<0.05)。结论LADA患者体内25(OH)D3水平越低,中性粒细胞计数、CRP水平越高,胰岛细胞自身抗体种类越复杂。
Objective To study the relationship between different levels of vitamin D3[25(OH)D3]with islet cell autoantibodies and inflammation indicators in adult patients with latent autoimmune diabetes(LADA).Methods Sixty-seven patients with LADA clinically diagnosed in this hospital from August 2016 to December 2019 were selected and divided into the sufficient group,insufficient group and lack group according to the 25(OH)D3 level.The general data were collected in each group.The islet autoantibodies,blood routine,CRP and SAA levels were detected.Results The neutrophil count and CRP level in the lack group were higher than those in the sufficient group,and the neutrophil count in the insufficient group was higher than that in the sufficient group,and the differences were statistically significant(P<0.05).The 25(OH)D3 level had significantly negative correlation with WBC count,neutrophil count and CRP level(P<0.05).In the comparison among 5 kinds of islet cell autoantibodies positive rates,GADA>ZnT-8A>IA-2A>IAA>ICA.There was no statistically significant difference in the islet cell autoantibodies positive rates among the three groups(P>0.05).The positive ratio of 1 type of islet cell autoantibody in the sufficient group was higher than that in the lack group,the positive ratio of≥2 types of islet cell autoantibody was lower than that in the lack group,and the differences were statistically significant(P<0.05).Conclusion The lower the 25(OH)D3 level in the patients with LADA,the higher the neutrophil count and CRP level,and the more complex the islet autoantibodies types.
作者
李德琴
张瑞
耿丽萍
LI Deqin;ZHANG Rui;GENG Liping(Department of Clinical Laboratory,Qinghai Provincial People′s Hospital,Xining,Qinghai 810003,China)
出处
《国际检验医学杂志》
CAS
2021年第2期185-188,共4页
International Journal of Laboratory Medicine
