摘要
目的:比较依托考昔和秋水仙碱治疗痛风急性发作的临床疗效。方法:选取某院2017年6月~2019年6月收纳的急性痛风患者160例,采用随机数表法将其分为A组与B组各80例,A组患者进行依托考昔治疗,B组患者利用秋水仙碱治疗,比较两组临床疗效、治疗前后的疼痛指数和治疗期间不良反应发生率。结果:A组患者临床疗效总有效率为96.25%,B组患者总有效率为95.00%,两组患者临床疗效总有效率经比较差异无统计学意义(P>0.05);两组患者治疗前后VAS评分经比较均无统计学意义(P>0.05),治疗后两组患者疼痛指数均显著下降低于治疗前;A组患者不良反应发生率为1.25%,B组患者不良反应发生率为5.00%,B组患者不良反应发生率要比A组患者稍高一些,差异无统计学意义(P>0.05)。结论:依托考昔和秋水仙碱治疗痛风急性发作均有显著疗效,能够有效改善患者病情,但依托考昔对患者机体影响较小,安全性更高,不会对患者胃肠道造成较大影响。
Objective:To compare the clinical effect of etoricoxib and colchicine in relieving acute attack of gout.Methods:A total of 160 patients with acute gout admitted to a hospital from June 2017 to June 2019 were selected and divided into group A and group B by random number table method,with 80 cases in each group.The group A were treated with etoricoxib,and group B was treated with colchicine,then the clinical efficacy,pain index before and after treatment and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate was 96.25%in group A and 95.00%in group B.There was no statistically significant difference between the two groups(P>0.05).There was no significant difference in VAS scores between the two groups before and after treatment(P>0.05).The pain indexes of the two groups after treatment were significantly lower than that before treatment.The incidence of adverse reactions was 1.25%in group A and 5.00%in group B.The incidence of adverse reactions in group B was slightly higher than that in group A,and the difference was not statistically significant(P>0.05).Conclusion:Both etoricoxib and colchicine have significant curative effect in the treatment of acute gout attack,which can effectively improve the patient's condition,but the effect of etoricoxib on the patient's body is small,the safety is higher,and it will not have a great effect on the gastrointestinal tract of the patients.
作者
斯璐露
朱小春
Si Lulu;Zhu Xiaochun(Wenzhou Medical University,Wenzhou 325035;No.1 Affiliated Hospital of Wenzhou Medical University,Wenzhou 325035)
出处
《数理医药学杂志》
2021年第1期81-83,共3页
Journal of Mathematical Medicine
