摘要
肺癌是我国最常见的、预后较差的恶性肿瘤之一,大多数患者确诊时即为晚期。有研究表明肺癌患者的微生态特征有别于健康人群,呼吸道的微生物可以通过多种机制影响肺癌的发生发展。近年来微生物组学与疾病相关性研究已成为继人类基因组计划又一研究热点,然而目前有关肺癌与呼吸道微生物组特征的研究相对较少,因此,需要更深入地探讨肺癌与微生物菌群间的潜在联系,通过研究呼吸道微生物在肺癌发生发展中的作用机制,以期在为肺癌的临床诊治、预后评估提供更明确的科学依据。本文对目前关于微生物菌群与肺癌相关研究进行综述,并为临床上诊断与治疗肺癌提供新的思路。
Lung cancer is one of the most common malignant tumors with poor prognosis in China, and most patients are diagnosed as advanced patients. Studies have shown that the microecological characteristics of lung cancer patients are different from healthy people, and the microorganisms of the respiratory tract can affect the occurrence and development of lung cancer through various mechanisms. In recent years, the study of the correlation between microbiome and disease has become another research hotspot following the Human Genome Project. However, at present, there are relatively few studies on the characteristics of lung cancer and respiratory microbiome. Therefore, it is necessary to further explore the potential relationship between lung cancer and microbial flora. By studying the mechanism of action of respiratory microorganisms in the development of lung cancer, it is expected to provide a clearer scientific basis in the clinical diagnosis, treatment and prognosis assessment of lung cancer. This article reviews the current researches on microbial flora and lung cancer, and provides new ideas for clinical diagnosis and treatment of lung cancer.
作者
刘国慧
谷安鑫
鄂明艳
Guohui LIU;Anxin GU;Mingyan E(Department of Radiation Oncology,Harbin Medical University Cancer Hospital,Harbin 150040,China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2020年第11期948-953,共6页
Chinese Journal of Lung Cancer
