摘要
肺癌生物靶向治疗主要有酪氨酸激酶抑制剂、血管生长因子受体抑制剂、免疫检查点阻滞剂、免疫细胞治疗等,这些治疗方法的作用机制各有差异,临床上常见药后不良反应主要为皮疹、腹泻等。结合不良反应与疗效的关系以及中医“瞑眩反应”理论,将治疗伴随的皮疹和腹泻建议定为“药疹”和“药泄”,充分利用“瞑眩反应”理论在中西医融合治疗肺癌中的指导价值,辨证地认识与处理生物靶向治疗的不良反应,以丰富“瞑眩反应”的内涵。
Biological targeted therapies for lung cancer mainly include tyrosine kinase inhibitors,vascular growth factor receptor inhibitors,immune checkpoint inhibitors and immunological cytotherapy.Although the mechanisms of these therapies are different,side effects in clinic are mainly skin rash and diarrhea.Based on the relationship between these reactions and their corresponding curative effects as well as the theory of “dizziness response” in traditional Chinese medicine(TCM),we suggest that the skin rash and diarrhea should be defined as “drug eruption” and “drug diarrhea”.We should make full use of the guidance value in the theory of “dizziness response” in the treatment of lung cancer using integrated traditional Chinese and western medicine,to dialectically understand and cope with the adverse reactions in biological targeted therapies,so as to enrich the connotation of “dizziness response”.
作者
罗斌
刘海涛
李和根
田建辉
Luo Bin;Liu Haitao;Li Hegen;Tian Jianhui(Oncology Department,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Oncology Institute of Traditional Chinese Medicine,Shanghai Institute of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《世界中医药》
CAS
2019年第9期2519-2523,共5页
World Chinese Medicine
基金
国家自然科学基金面上项目(81774166)
上海市卫计委市级医疗卫生优秀学术带头人培养计划资助项目(2017BR044)
上海市申康医院发展中心市级医院新兴前沿前沿技术联合攻关项目(SHDC12016114)
关键词
肺癌
生物靶向
瞑眩反应
邪有出路
理论传承
学术创新
药疹
药泄
Lung cancer
Biological targeted
Dizziness response
The evil can be expelled out of the body
Theoretical inheritance
Academic innovation
Drug eruption
Drug diarrhea
