摘要
目的分析在介入治疗食管狭窄患者中应用依托咪酯(1:1)混合异丙酚的效果。方法将2018年8月—2020年5月期间在医院麻醉科中ASA评分Ⅱ级或Ⅲ级,行纤维内镜介入治疗食管狭窄的60例患者纳入研究,并随机设为两个组别,其中对照组(30例)实施异丙酚复合芬太尼治疗,依托咪酯组(30例)实施异丙酚与依托咪酯(1:1)混合治疗。观察两组患者手术时间和苏醒时间,统计麻醉后的注射痛,循环抑制,呼吸抑制,体动反应等不良反应发生率。结果对照组和依托咪酯组苏醒时间分别为(6.93±1.35)min、(6.73±1.48)min;手术时间分别为(36.63±2.63)min、(37.53±2.79)min,两组差异均无统计学意义(P>0.05)。依托咪酯组呼吸抑制、循环抑制、注射痛发生率明显低于对照组;但肌颤发生率高于对照组,两组差异有统计学意义(P<0.05)。在体动反应发生率上,两组患者差异无统计学意义(P>0.05)。结论在电子内镜介入治疗食管狭窄患者中,依托咪酯(1:1)混合异丙酚相较于异丙酚复合芬太尼能够更为明显的减少呼吸抑制、循环抑制、注射痛,并且苏醒时间差异较小,为患者提供良好的麻醉体验。
Objective To analyze the effect of etomidate(1:1)mixed propofol used in interventional treatment of Esophageal stricture.Methods From August 2018 to May 2020,60 patients(Asa GradeⅡorⅢ)with esophageal stricture were enrolled in this study and randomly assigned to two groups,the Control Group(30 cases)was treated with propofol combined with fentanyl,and the etomidate group(30 cases)was treated with propofol combined with Etomidate(1:1).The time of operation and recovery were observed,and the incidence of injection pain,circulation inhibition,inhalation inhibition,kinesis reaction and other adverse reactions after anesthesia were analyzed.Results The recovery time of the control group and etomidate group were(6.93±1.35)min and(6.73±1.48)min respectively;the operation time was(36.63±2.63)min and(37.53±2.79)min respectively,and there was no significant difference between the two groups(P>0.05).The incidence of respiratory depression,circulatory depression and injection pain in etomidate group was significantly lower than that in control group,but the incidence of muscle fibrillation in etomidate group was higher than that in control group(P<0.05).There was no significant difference in the incidence of body dynamic responset between the two groups(P>0.05).Conclusion Etomidate(1:1)combined with propofol can significantly reduce inhalation inhibition,circulation inhibition and injection pain in patients with esophageal stricture treated by endoscopic interventional therapy,moreover,the difference of recovery time is small,which provides good anesthesia experience for patients and is worth popularizing.
作者
宫萍
GONG Ping(Department of Anesthesiology,The Third Affiliated Hospital of Xuzhou Medical University,Xuzhou Jiangsu 221000,China)
出处
《中国继续医学教育》
2020年第34期133-136,共4页
China Continuing Medical Education
