摘要
目的比较不同容积比的丙泊酚-依托咪酯混合液用于无痛胃镜诊疗中的效果,探究两者最佳容积比。方法选择无痛胃镜检查的患者80例,ASA分级Ⅰ~Ⅱ级,年龄43~68岁,根据丙泊酚(10mg/ml),依托咪酯(2mg/ml)混合容积比,随机分为A(容积比为1∶1)、B(3∶2)、C(2∶1)和D(3∶1)4组,每组各20例。记录诱导、操作和苏醒时间;诱导前(T0)、进镜前(T1)、进镜后(T2)MAP、HR和Narcotrend指数(NTI);追加药物情况;不良反应。结果 A组苏醒时间显著长于其余3组(P<0.05),C组苏醒时间显著短于B组和D组(P<0.05);各组T1,T2时MAP和NTI均较T0显著下降(P<0.05);A组追加药物次数及例数显著高于其余3组(P<0.05),C组追加药物次数及例数显著低于B组和D组(P<0.05);D组注射痛发生率显著高于其余3组(P<0.05),A组肌颤、呛咳和呃逆发生率显著高于其余3组(P<0.05),B组肌颤、呛咳和呃逆发生率显著高于C组(P<0.05)。结论容积比为2∶1丙泊酚-依托咪酯混合液苏醒最快、不良反应率最低,值得临床推广使用。
Objective To compare the effect of propofol-etomidate mixed solution with different volume ratio in painless gastroscopy diagnosis and treatment,and to explore the optimal volume ratio. Methods Eighty patients with ASA I or Ⅱ,ranging in age from 43 to68,were divided into four groups in random according to the volume ratio of propofol to etomidate： group A（ volume ratio of 1 ∶ 1）,group B（ 32）,group C（ 2∶ 1） and group D（ 3∶ 1）,with 20 patients in each group. The anesthesia induction,operation and recovery time were recorded; MAP,HR and NTI were recorded before induction（ T0）,before（ T1） and after（ T2） the gastroscope was insered; The additive medications and adverse reaction were recorded. Results The recovery time in group A was significantly longer than that of the other groups（ P〈0. 05）,the recovery time in group C was significantly lower than that of the group B and D（ P〈0. 05）; MAP and NTI at T1 and T2 point were significantly lower than that at T0 in all groups（ P〈0. 05）; The propofol addings in group A were more frequent than that of the other groups（ P〈0. 05）,the propofol addings in group C were less than that of the group B and D（ P〈0. 05）; The injection pain was more common in group D compared with the other groups（ P〈0. 05）,myoclonus,choking and hiccupping were more common in group A compared with the other groups（ P〈0. 05）,myoclonus,choking and hiccupping were more common in group B compared with group C（ P〈0. 05）. Conclusion The propofol-etomidate mixture with a volume ratio of 2∶ 1 has the least side effects and is worthy of clinical application.
作者
刘伟伟
黄科昌
于天英
李林艳
何思梦
任占杰
LIU Weiwei1, HUANG Kechang1,2, YU Tianying3 , LI Linyan3, HE Simeng1, REN Zhanjie1,2(1. Department of Anesthesiology, Weifang Medical University, Weifang 261053, China ; 2.Department of Pain Medicine, the Affiliated Hospital of Weifang Medical University; 3.Department of Anesthesiology, the Affiliated Hospital of Weifang Medical Universit)
出处
《潍坊医学院学报》
2018年第1期11-13,共3页
Acta Academiae Medicinae Weifang
关键词
丙泊酚
依托咪酯
胃镜
给药法
Propofol
Etomidate
Gastroscopy
Drug administration
