摘要
目的通过分析新型冠状病毒肺炎(简称新冠肺炎)患者治疗前后血浆总蛋白(TP)和白蛋白(ALB)水平的变化,探讨TP和ALB在新冠肺炎患者肝功能损伤诊断中的应用价值。方法自2019年12月21日起,赤壁市蒲纺医院(同济赤壁医院)收治25例新冠肺炎确诊患者(其中重症患者1例),所有患者入院时(治疗前)和治疗5 d(治疗后)进行两次常规血生化检测,比较治疗前后TP、ALB、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、直接胆红素(DBil)、肌酐(Cr)、二氧化碳结合力(CO2CP)、尿酸(UA)、总胆红素(TBil)、血尿素氮(BUN)水平的变化。结果25例新冠肺炎患者TP、ALB、UA水平均较治疗前明显降低〔TP(g/L):65.75±5.06比72.61±5.09,ALB(g/L):36.82±4.68比43.87±5.15,UA(mmol/L):221.03±9.28比284.39±12.40〕,差异均有统计学意义(均P<0.05);治疗后患者ALT较治疗前有所升高(U/L:55.87±4.61比36.39±2.41),但差异无统计学意义(P>0.05);其余各指标治疗前后变化不大,差异均无统计学意义(均P>0.05)。结论新冠肺炎患者病程中肝功能损伤明显,TP、ALB对新冠肺炎患者肝功能损伤具有一定的诊断价值,临床应予以关注,加强对肝功能的监测,对肝功能指标不佳患者及时给予护肝治疗。
Objective To analyze the changes of plasma total protein(TP)and albumin(ALB)levels of patients with coronavirus disease 2019(COVID-19)before and after treatment,and to investigate the application value of TP and ALB in liver function damage of patients with COVID-19.Methods Since December 21,2019,totally 25 patients were diagnosed with COVID-19 and admitted to Pufang Hospital of Chibi City(Tongji Chibi Hospital),including one case of severe type.All the patients received routine blood biochemical tests at admission(before treatment)and after 5 days of treatment(after treatment).The levels of TP,ALB,alanine aminotransferase(ALT),aspartate aminotransferase(AST),direct bilirubin(DBil),serum creatinine(Cr),carbon dioxide combining power(CO2CP),uric acid(UA),total bilirubin(TBil)and blood urea nitrogen(BUN)were compared before and after treatment.Results The TP,ALB and UA levels of 25 patients with COVID-19 were significantly lower than those before treatment[TP(g/L):65.75±5.06 vs.72.61±5.09,ALB(g/L):36.82±4.68 vs.43.87±5.15,UA(mmol/L):221.03±9.28 vs.284.39±12.40],with significant differences(all P<0.05).After treatment,the ALT level was higher than that before treatment(U/L:55.87±4.61 vs.36.39±2.41),but the difference was not statistically significant(P>0.05).There were no significant differences in other indexes before and after treatment(all P>0.05).Conclusions The liver function injury in progression of patients with COVID-19 is obvious.TP and ALB have certain diagnostic values for the liver function injury in patients with COVID-19.The clinicians should pay attention to the liver function of COVID-19 patients,strengthen the monitoring of liver function,and give timely liver protection and support treatment to patients with poor liver function indexes.
作者
徐亚林
张梦晗
杨群
马梦兰
李澄
张亚丽
Xu Yalin;Zhang Menghan;Yang Qun;Ma Menglan;Li Cheng;Zhang Yali(Clinical Laboratory,Pufang Hospital of Chibi City(Tongji Chibi Hospital),Chibi 437321,Hubei,China;Department of Infectious Disease,Pufang Hospital of Chibi City(Tongji Chibi Hospital),Chibi 437321,Hubei,China)
出处
《实用检验医师杂志》
2020年第4期244-246,共3页
Chinese Journal of Clinical Pathologist
