摘要
目的:分析慢性高原病患者肝功能、肾功能、血脂、血浆蛋白及血清酶等血生化的变化。方法:于2003-03/2005-08选择移居海拔4300m3个月以上的汉族男性青年323名,其中慢性高原病患者87名,为慢性高原病组,其余236名为无慢性高原病组。清晨抽取空腹静脉血5mL,用ACCUTETDA-40FR全自动生化分析仪检测血清总胆红素、直接胆红素、总蛋白、白蛋白、尿素氮、肌酐、尿酸、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、丙氨酸氨基转换酶、门冬氨酸氨基转换酶、γ-谷氨酰转移酶、碱性磷酸酶。以血红蛋白(18g<血红蛋白<21g,记0分,血红蛋白≥21g,记3分)及动脉血氧饱和度(动脉血氧饱和度≤85%,记3分)记分。分别以1,2,3分表示轻、中、重度。无慢性高原病总记分为0～5分,轻度为6～10分,中度为11～14分,重度为15分或更高。结果:纳入汉族男性青年323名,均进入结果分析。与无慢性高原病组比较慢性高原病组较血清总胆红素、总胆固醇、三酰甘油、门冬氨酸氨基转换酶、丙氨酸氨基转换酶、γ-谷氨酰转移酶增高,差异显著(P<0.05),总蛋白、白蛋白、尿素氮、尿酸增高,差异非常显著(P<0.01),高密度脂蛋白胆固醇降低,差异显著(P<0.01),其余无统计学意义(P>0.05)。结论:慢性高原病引起肝功能、肾功能等多项指标异常,提示多脏器损伤。
AIM： To analyze the changes of live function, renal function, blood lipid, plasma protein and serum enzyme in patients with chronic mountain sickness （CMS）. METHODS： From March 2003 to August 2005, 323 male youths of Han who emigrated to live for more than 3 months at high altitude of 4 300 m were divided into 2 groups： CMS group （n=87） and non-CMS group （n=236）. The 5 mL venous blood were drawn in the early morning on a empty stomach, and ACCUTE TDA-40FR automatic biochemistry analyzer was used to detect serum total bilirubin （STB）, serum direct bilirubin （SDB）, total protein （TP）, albumin （ALB）, blood urea nitrogen （BUN）, creatinine （Cr）, uric acid （UA）, triacylglycerol （TG）, total cholesterol （TC）, high density lipopro- tein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, γ-glutamyl transferase （γ-GT）, alkaline phosphatase （ALP）. The subjects were scored with hemoglobin （Hb） （score 0 as 18 g 〈 Hb 〈 21 g, score 3 as Hb ≥ 21 g） and arterial oxygen saturation （AOS） （score 3 as AO ≤85%）, and the CMS sufferers were graded as 1,2 and 3, which meant mild, moderate and severe level respectively while the non-CMS people were ranked totally from 1 to 5, mild as 6-10, moderate as 11-14 and severe as 15 or above. RESULTS： All the 323 young men were involved in the result analysis. Compared with the non-CMS group, STB, TC, TG, AST, ALT, γ-GT were increased in CMS group, with the significant difference （P 〈 0.05）. TP, ALB, BUN, and UA were also enhanced in CMS group, with the strikingly significant difference （P 〈 0.01）. However, HDL-C was reduced compared with non-CMS group, with significant difference （P 〈 0.01）, and there was no difference in other markers （P 〉 0.05）. CONCLUSION： The multinomial indexes of liver function and renal function are abnormal in CMS sufferers, which indicate many viscera are damage
出处
《中国临床康复》
CSCD
北大核心
2006年第36期14-15,共2页
Chinese Journal of Clinical Rehabilitation
