摘要
目的:分析老年胆道系统恶性肿瘤根治术患者的远期生存状态并探讨影响其预后的临床病理因素。方法:回顾性分析2011年1月—2015年12月在南京医科大学第一附属医院行胆道系统恶性肿瘤根治术的143例>65岁患者的临床病理资料及随访资料,采用Kaplan-Meier法单因素分析和COX单因素及多因素分析统计其总生存期(overall survival,OS)并分析其影响因素。结果:所有患者的中位OS为20.0个月。通过Kaplan-Meier法及COX回归风险模型单因素分析,结果显示浸润深度、淋巴结转移情况、组织分级、脉管侵犯、切缘阳性与否、术前乳腺脱氢酶(lactate dehydrogenase,LDH)水平与总生存期相关;COX多因素分析显示浸润深度、组织分级、术前LDH水平是老年胆道系统恶性肿瘤根治术患者的危险因素。结论:老年胆道系统恶性肿瘤根治术患者总生存期与浸润深度、组织分级、术前LDH水平相关。
Objective:This studt aims to explore the prognostic factors in elderly operable biliary tract cancer patients treated with radical resection. Methods:The clinicopathologic and follow-up data of 143 elderly patients(>65 years old)with biliary tract cancer treated with radical resection from January 2011 to December 2015 were analyzed retrospectively. Results:Univariate analysis showed that depth of tumor invasion,lymph node involvement,histological differentiation,lymphovascular invasion,resection margin,lactate dehydrogenase(LDH)level were correlated to recurrence and metastasis of biliary tract cancer after radical resection. Multivariate analysis showed that depth of tumor invasion,histological differentiation and LDH level were independent factors affecting the prognosis of elderly biliary tract cancer patients. Conclusion:The overall survival of elderly operable biliary tract cancer patients was correlated with tumor invasion,histological differentiation and LDH level before radical resection.
作者
邱天竹
李晓林
Qiu Tianzhu;Li xiaolin(Department of Oncology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Geriatric Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第12期1751-1754,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金面上项目(81672411).
关键词
胆道系统恶性肿瘤
根治术
老年人
生存分析
预后影响因素
biliary tract cancer
radical resection
elderly patients
survival analyse
prognostic factors
