摘要
目的比较换血治疗合并强光源光疗及单纯强光源光疗并发症的不同及住院时间的差别。方法回顾性分析121例足月新生儿高胆红素血症病例,比较换血合并使用强光源光疗组患儿及单纯用强光源光疗组患儿并发症的发生率及住院时间,以及球浆比1:1含枸橼酸盐抗凝剂的红细胞和新鲜冻存血浆换血组与球浆比2:1含枸橼酸盐抗凝剂的红细胞和新鲜冻存血浆换血组患儿贫血发生率。结果换血合并使用强光源光疗组患儿并发症的发生率高于单纯强光源光疗组患儿并发症的发生率,差异有统计学意义(P<0.05),而两组患儿住院时间无统计学意义(P>0.05);换血组中比较1:1换血组比2:1换血组贫血发生率高,差异有统计学意义(P<0.05)。结论达到换血指标的新生儿高胆红素血症患儿均应考虑先光疗4~6 h并复测血清总胆红素水平,并再次评估是否需要换血治疗,以减少并发症的发生,如采用换血疗法,建议采用2:1换血。
Objective To explore the difference in the incidence of complications and hospitalization time between exchange transfusion combined with intensive phototherapy and single intensive phototherapy in the treatment of neonatal hyperbilirubinemia.Methods We retrospectively analyzed the data of 121 hyperbilirubinemia in term infants.We compared the difference in the incidence of complications and the hospitalization time between the exchange transfusion combined with intensive phototherapy and single intensive phototherapy in the treatment of neonatal hyperbilirubinemia.We also studied the incidences of anemia when we use different volume ratios of red blood cells and plasma.Results There were more complications in the group of exchange transfusion combined with intensive phototherapy than the intensive phototherapy group,otherwise there was no difference in the hospitalization time between the two groups.The incidence of anemia of the 1:1 exchange transfusion group was higher than that of the 2:1 exchange group.Conclusions All neonates with hyperbilirubinemia should be considered phototherapy for 4 hours or 6 hours and reassess whether they need exchange transfusion therapy to reduce the incidence of complications.If the exchange transfusion therapy is used,it is suggested that the volume ratios of red blood cells to plasma is 2:1 rather than 1:1.
作者
许小志
杨景晖
XU Xiao-zhi;YANG Jing-hui(Dept.of Pediatrics,The First People’s Hospital of Yunnan Province,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2020年第11期44-48,共5页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81860281)
云南省卫生内设研究机构基金资助项目(2018NS234)
云南省高层次卫生计生技术人才培养经费资助项目(D-2017054)。
关键词
换血
强光源光疗
新生儿高胆红素血症
Exchange transfusion
Intensive phototherapy
Neonatal hyperbilirubinemia
