摘要
目的:观察芪茯化浊汤治疗发作间歇期和慢性期痛风的疗效和安全性。方法:160例符合纳入标准的痛风患者被按照治疗方式的不同分为治疗组和对照组,各80例。治疗组口服芪茯化浊汤联合非布司它,对照组口服非布司它联合碳酸氢钠片,疗程为12周。比较各组治疗前后痛风发作的次数,关节疼痛的程度,血尿酸、肌酐、丙氨酸氨基转移酶水平,合并使用止痛药的例数和不良反应,治疗结束后随访12周。结果:治疗组总有效率91.25%(73/80),高于对照组的83.75%(67/80)(χ~2=0.16,P<0.05)。治疗组对改善痛风发作的次数、关节疼痛的程度优于对照组(P<0.05)。治疗组对血尿酸的改善优于对照组(P<0.05)。两组患者治疗后血肌酐和丙氨酸氨基转移酶的比较差异无统计学意义。治疗组合并使用止痛药的人数优于对照组(P<0.05)。不良反应方面,治疗组出现发热2例,肝功能异常2例,肾功能异常6例,胃肠道反应3例;对照组发热1例,肝功能异常2例,肾功能异常8例,胃肠道反应5例;两组患者不良反应发生率的比较差异无统计学意义。结论:芪茯化浊汤可有效减少发作间歇期和慢性期痛风急性发作次数和关节疼痛程度,能够有效控制血尿酸水平,减少合并使用止痛药的例数,不良反应少,适合临床推广使用。
Objective: To observe the efficacy and safety of Qifu Huazhuo decoction in treating intermittent and chronic gout. Method: A total of 160 eligible patients with intermittent and chronic gout were divided into intervention group and control group according to treatment methods,80 cases in each group. Qifu Huazhuo decoction combined with febuxostat was given in intervention group by oral administration,while the patients in control took febuxostat combined with sodium bicarbonate tablet. After twelve weeks of treatment in both groups,the onset frequency of gout,the degree of joint pain,the levels of uric acid,creatinine,alanine transaminase in the blood,number of cases to use analgesics and adverse events were recorded compared before and after treatment. Twelve weeks follow-up was also conducted after the treatment. Result: The total effective rate was 91.25%(73/80)in intervention group,higher than 83.75%(67/80)in control group,with a significant difference between two groups (χ~2=0.16, P<0.05). Intervention group was superior to control group in improvement of onset frequency of gout,joint pain(P<0.05),and blood uric acid(P<0.05). There was no significant difference between two groups in blood creatinine and alanine transaminase. The number of patients using analgesics was less in intervention group(P<0.05). In terms of adverse reactions,there were two cases of fever, two cases of abnormal liver function, six cases of abnormal kidney function and three cases of gastrointestinal reaction after the treatment in intervention group. While for control group,there were one case of fever, two cases of abnormal liver function, eight cases of abnormal kidney function and five cases of gastrointestinal reaction,without significant differences between two groups. Conclusion: The Qifu Huazhuo decoction can effectively reduce the onset frequency of gout and the degree of joint pain in intermittent and chronic phases,effectively control the level of blood uric acid,and reduce the number of cases using analgesics,with less adv
作者
夏璇
李文杰
张磊
储永良
XIA Xuan;LI Wen-jie;ZHANG Lei;CHU Yong-liang(The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510140,China;Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510006,China;Zhuhai Branch of Guangdong Provincial Hospital of Chinese Medicine,Zhuhai 519015,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第23期120-124,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点研发计划项目(2018YFC1705203)
广东省中医院中医药科学技术研究专项(YN2019ML15)。
