摘要
临床上恶性肿瘤的发病率、死亡率较高,尤其是欠发达地区或国家。近年来随着人们健康意识、生活水平及医疗水平的不断提高,恶性肿瘤的发病率、死亡率有所下降。目前恶性肿瘤临床治疗西医多行手术切除术或放射治疗、化学药物治疗、靶向药物治疗、免疫治疗等现代手段,但患者术后肿瘤易复发、易转移、不良反应较大、预后较差及耐药性等问题,都严重的影响临床疗效及患者的生命质量。中医学认为恶性肿瘤归属于中医的"积聚""癥瘕"等范畴,病因主要是内外因两方面,内因主要是正气不足,外因多为机体感受六淫之外邪、七情刺激等致病因素,使机体气血、阴阳的失衡、脏腑功能障碍等诸般不和而导致恶性肿瘤的发生。病机多为本虚标实,本虚主要是正气不足,以气滞、血瘀、痰凝、毒结为标,治则上宜软坚散结,活血解毒,调和阴阳。而对于临床结块类的恶性肿瘤,软坚散结法为首选。软坚散结类中草药广泛应用于临床恶性肿瘤的治疗,且临床疗效显著。因此,近年来软坚散结类中草药抗肿瘤作用机制及临床研究成为国内外研究的热点,结合近10年国内外文献,从实验药理研究与临床研究两方面对软坚散结类中草药治疗恶性肿瘤的研究进展进行综述,以期为软坚散结类中草药临床抗肿瘤应用提供参考。
Clinically,the incidence and mortality of malignant tumors are relatively high,especially in underdeveloped regions or countries. In recent years,with the continuous improvement of people’s health awareness,living standards and medical standards,the incidence and mortality of malignant tumors have been declining. At present,malignant tumors are mostly treated by western medicine therapies in clinic,such as surgical resection or radiation therapy, chemical drug therapy, targeted drug therapy and immunotherapy.However,patients with postoperative tumors are prone to relapse and metastasis,with severe adverse reactions and a poor prognosis. And drug resistance and other issues have a serious impact on clinical efficacy and the quality of life of patients. Traditional Chinese medicine believes that malignant tumors belong to the "accumulation" and "abdominal mass",with both internal and external etiologies. The internal etiology is mainly the insufficient anti-pathogenic energy. The external etiology is mainly six exogenous pathogenic factors to the body seven emotional stimulations. Pathogenic factors,such as deficiencies of Qi and blood,imbalance of Yin and Yang and visceral dysfunction,which lead to the occurrence of malignant tumors. The pathogenesis is mostly based on the asthenia in origin and access in superficiality. The asthenia in origin is mainly due to the insufficient anti-pathogenic energy,with Qi stagnation,blood stasis,phlegm coagulation,and toxic knot as the symptoms.For malignant tumors,like modules,the method for softening hardness to dissipate stagnation is the first choice.Chinese herbal medicine for softening hardness to dissipate stagnation is widely used for malignant tumors in clinic,with a remarkable clinical efficacy. Therefore,in recent years,anti-tumor mechanism and clinical studies of Chinese herbal medicine for softening hardness to dissipate stagnation have become a hotspot at home and abroad. This paper combines the domestic and foreign literatures of the effect of Chinese herbal med
作者
王栋
高宇
张佳
朱潇雨
王晞星
WANG Dong;GAO Yu;ZHANG Jia;ZHU Xiao-yu;WANG Xi-xing(Shanxi Institute of Traditional Chinese Medicine(TCM),Taiyuan 030012,China;Shanxi Provincial Hospital of TCM,Taiyuan 030012,China;China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第23期219-225,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山西省应用基础研究项目(2016021168)
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2013〕47号)。
关键词
恶性肿瘤
软坚散结
中草药
中医
malignant tumor
softening hardness to dissipate stagnation
Chinese herbal medicine
Chinese medicine
