摘要
恶性纤维组织细胞瘤(MFH)被认为是一种具有组织学来源且分化方向尚未明确的未分化多形性肉瘤,好发于中老年人,但近年来其患者群体呈年轻化趋势。MFH主要好发于四肢、躯干、脏器及后腹腔等部位,多呈浸润性生长且术后复发率和转移率极高,患者预后多不良。目前,其常见的诊断方法有X线、超声、磁共振成像、CT、正电子发射计算机断层显像-CT等影像学检查方法,以及病理组织学检查、免疫组织化学标志物检测等,且常见的检查手段大多需要进行大量的鉴别诊断并结合临床表现才可对MFH进行明确诊断。随着分子生物学的不断发展,越来越多的基因被证实在肿瘤的发生、发展中起了至关重要的作用,未来其将为肿瘤的诊断与治疗提供新方向。
Malignant fibrous histiocytoma(MFH) is considered to be an undifferentiated pleomorphic sarcoma with a histological origin and an unclear differentiation direction.Most of them occur in the elderly,but in recent years,the patient population is getting younger.MFH mainly occurr in the limbs,trunk,viscera organs,and posterior abdominal cavity,most of which show invasive growth,and the postoperative recurrence rate and metastasis rate are extremely high,presenting poor prognosis.At present,the common diagnostic methods of MFH include X-ray,ultrasound,magnetic resonance imaging,CT,positron emission tomography-CT and histopathological examination,immunohistochemical markers detection,etc.Most of the common diagnostic methods need a lot of differential diagnosis and clinical manifestations in order to achieve an exact diagnosis of MFH.With the development of molecular biology,more and more genes have been proved to play important roles in the occurrence and development of tumors,which will provide a new direction for the diagnosis and treatment of tumors in the future.
作者
赵子文
姜博
谷文光
ZHAO Ziwen;JIANG Bo;GU Wenguang(Department Three of Orthopedics,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2020年第21期4230-4234,共5页
Medical Recapitulate
基金
国家自然科学基金(81472512)。
关键词
恶性纤维组织细胞瘤
影像学诊断
组织病理学检查
Malignant fibrous histiocytoma
Imaging diagnosis
Histopathological examination
