摘要
FOXO3a是Forkhead转录因子亚家族O的一个重要成员,通过磷酸化、泛素化降解、微小RNA(miRNA)等方式在促进细胞凋亡、诱导细胞周期阻滞、抑制肿瘤细胞增殖、抑制肿瘤转移等中发挥重要作用。研究发现增强FOXO3a表达能够抑制前列腺癌细胞生长,本文主要对FOXO3a在前列腺癌中的调控信号通路研究进展进行综述,拟为前列腺癌临床诊断和靶向治疗提供新的思路。
FOXO3 a is an important member of the FOXO subfamily of Forkhead transcription factors, which plays an important role in promoting cell apoptosis, inducing cell cycle arrest, inhibiting cell proliferation and suppressing tumor metastasis through phosphorylation, ubiquitination-mediated degradation and microRNA. Studies show that upregulated expression of FOXO3 a can inhibit the growth of PCa cells. This review summarizes the advances in the studies of the FOXO3 a signaling pathway in PCa, aiming to provide some new ideas on the clinical diagnosis and targeted therapy of the malignancy.
作者
陶燕
李兰兰(综述)
刘善辉
洪梅(审校)
TAO Yan;LI Lan-lan;LIU Shan-hui;HONG Mei(Research Institute of Urology/Key Laboratory of Urological Diseases of Gansu Province/Nephro-Urological Clinical Center of Gansu Province,Lanzhou University Second Hospital,Lanzhou,Gansu 730030,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2020年第8期745-750,共6页
National Journal of Andrology
基金
国家自然科学基金(81302240)
兰州大学第二医院“萃英科技创新”计划(CY2019-QN05、CY2018-QN13)。
