摘要
作为一种必需氨基酸,色氨酸(tryptophan,Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine,Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、CO2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受体(aromatic hydrocarbon receptor,AhR)、孕烷X受体(progesterone X receptor,PXR),诱导胰高血糖素样肽-1(glucagon like peptide-1,GLP-1)释放,改善肠道抗氧化能力及线粒体功能,促进5-HT释放等机制参与调节机体健康。这里通过阐述Trp、Trp代谢过程以及Trp代谢物的作用机制,探讨Trp及其代谢产物对肠粘膜免疫屏障的调节作用。
As an essential amino acid,tryptophan(Trp)produces 5-hydroxytryptamine,niacin,CO2,quinoline and indole derivatives through serotonin(5-HT),kynurenine(Kyn)and microbial metabolic pathway.Trp and its metabolites can regulate body health by activating aromatic hydrocarbon receptor(AhR),progesterone X receptor(PXR),inducing the release of glucagon like peptide-1(GLP-1),improving intestinal antioxidant capacity and mitochondrial function,and promoting the release of 5-HT.In this review,we discussed the regulatory effect of Trp and its metabolites on intestinal mucosal immune barrier by elaborating the Trp,Trp metabolism and the mechanism of Trp metabolites.
作者
宋琦
王琦
Song Qi;Wang Qi(Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《国际免疫学杂志》
CAS
2020年第5期592-596,共5页
International Journal of Immunology
关键词
色氨酸
芳香烃受体
孕烷X受体
肠道免疫屏障
Tryptophan
Aromatic hydrocarbon receptor
Progesterone X receptor
Intestinal immune barrier
