摘要
目的观察连花清瘟胶囊联合盐酸左氧氟沙星氯化钠注射液治疗社区获得性肺炎(CAP)疗效及对莱斯特咳嗽问卷(LCQ)评分、血清炎性因子的影响。方法选取2017年11月—2019年11月华北理工大学附属医院呼吸科收治CAP患者280例,按随机数字表法分为观察组(140例)和对照组(140例),对照组给予盐酸左氧氟沙星氯化钠注射液静脉滴注治疗,观察组在对照组的基础上联合连花清瘟胶囊治疗。治疗7 d后,比较2组临床疗效及体温恢复正常、咳嗽消失、气促消失与肺部啰音消失时间,治疗前后的LCQ评分、社区获得性肺炎评分(CURB-65评分)和血清炎性因子水平变化,不良反应发生情况。结果观察组治疗总有效率高于对照组(97.14%vs.81.43%,χ^2=18.069,P=0.000)。观察组治疗后体温恢复正常、咳嗽消失、气促消失与肺部啰音消失时间均短于对照组(t/P=33.145/0.000、40.831/0.000、53.493/0.000、49.560/0.000)。治疗后,2组LCQ评分明显升高,CURB-65评分明显降低(P<0.01),且观察组LCQ评分高于对照组,CURB-65评分低于对照组(t/P=28.399/0.000、57.595/0.000)。治疗后,2组血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、半乳糖凝聚素-3(Gal-3)水平均明显降低(P<0.01);且观察组CRP、TNF-α、IL-17、Gal-3水平低于对照组(t/P=20.490/0.000、21.512/0.000、22.029/0.000、19.262/0.000)。2组不良反应事件发生率比较差异无统计学意义(P>0.05)。结论连花清瘟胶囊联合盐酸左氧氟沙星氯化钠注射液治疗CAP有较好的临床疗效,可提高患者生活质量,改善临床症状,降低炎性反应,安全性好。
Objective To observe the efficacy of Lianhuaqingwen capsule combined with Levofloxacin Hydrochloride and Sodium Chloride Injection in the treatment of community-acquired pneumonia(CAP)and its effect on the Lester Cough Questionnaire(LCQ)score and serum inflammatory factors.Methods From November 2017 to November 2019,280 cases of CAP patients were admitted to the Department of Respiration,North China University of Technology Affiliated Hospital,and were divided into observation group(140 cases)and control group(140 cases)according to the random number table.The control group was given levofloxacin hydrochloride chloride Intravenous drip treatment of sodium injection,the observation group was combined with Lianhuaqingwen capsule on the basis of the control group.After 7 days of treatment,compare the clinical efficacy and the time to normal body temperature,disappearance of cough,disappearance of shortness of breath and disappearance of pulmonary rales,LCQ score before and after treatment,community-acquired pneumonia score(CURB 65 score)and serum inflammatory factors in the two groups.Changes in levels and occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was higher than that in the control group(97.14%vs.81.43%,χ^2=18.069,P=0.000).After treatment,the observation group's body temperature returned to normal,the cough disappeared,the disappearance of shortness of breath and the disappearance of lung rales were shorter than those in the control group(t/P=33.145/0.000,40.831/0.000,53.493/0.000,49.560/0.000).After treatment,the LCQ score of the two groups was significantly increased,and the CURB 65 score was significantly decreased(P<0.01),and the LCQ score of the observation group was higher than that of the control group,and the CURB 65 score was lower than that of the control group(t/P=28.399/0.000,57.595/0.000).After treatment,the levels of serum C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin 17(IL 17),and galectin 3(Gal 3)in the two groups we
作者
逯阳
邵东风
孙晔
刘洋
付爱双
李立群
戈艳蕾
Lu Yang;Shao Dongfeng;Sun Ye;Liu Yang;Fu Aishuang;Li Liqun;Ge Yanlei(Department of Respiratory, Affiliated Hospital of North China University of Technology, Hebei Proveince,Tangshan 063000,China)
出处
《疑难病杂志》
CAS
2020年第11期1152-1156,共5页
Chinese Journal of Difficult and Complicated Cases
基金
河北省医学科学研究重点课题计划项目(20181710)。
关键词
连花清瘟胶囊
左氧氟沙星
社区获得性肺炎
临床疗效
炎性因子
Lianhuaqingwen capsule
Levofloxacin hydrochloride and sodium chloride injection
Community acquired pneumonia
Clinical efficacy
Inflammatory factors
