摘要
抑郁症是一种发病率高、复发率高、自杀率高、致残率高的神经精神类疾病,给个人、家庭以及社会带来极大负担。肠道菌群参与机体的众多生理调控,在情绪处理和行为方面发挥重要作用。研究发现个体肠道菌群变化与抑郁症发生密切相关。文章主要基于微生物-肠-脑轴探讨抑郁症的可能发病机制,对肠道菌群在单胺类神经递质、脑源性神经营养因子、炎症因子以及下丘脑-垂体-肾上腺(HPA)轴等4条通径中对抑郁症的作用进行综述。
Depression is a neuropsychiatric disease with high incidence,recurrence rate,suicide rate and disability rate,which brings immeasurable burden to individuals,families and society.Intestinal flora is involved in many physiological regulation of the body and plays an important role in emotional processing and behavior.Studies have found that changes in individual intestinal flora are closely related to the occurrence of depression.This paper mainly discusses the possible pathogenesis of depression based on the microbial-enteric-brain axis,and expounds the role of intestinal flora in monoamine neurotransmitter,brain-derived neurotrophic factor,inflammatory factor and HPA axis in the treatment of depression,so as to provide evidences for the treatment of intestinal flora in depression.
作者
陈珊珊
何阳(综述)
张志华
苏普玉(审校)
CHEN Shan-shan;HE Yang;ZHANG Zhi-hua;SU Pu-yu(Department of Maternal Child and Adolescent Health;Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Heifei 230032,Anhui,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第10期1093-1097,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81874268,81973064)。
关键词
肠道菌群
微生物-肠-脑轴
抑郁症
肠道微生物
intestinal flora
microbiome-intestinal-cerebral axis
depression
gut microbes
