摘要
利用菌群重建治疗疾病的临床证据越来越多,但是难以理解菌群重建治疗抗生素相关性菌群失调之外的其他疾病。反思微生物的属性、传统疾病分类的局限性和人体微生态的整合性,则可更好理解:菌群重建只治疗菌群失调相关性疾病。文中重点对微生物的致病性和益生性、粪菌移植的极端性、传统疾病分类的局限性、预测菌群重建对菌群失调相关性疾病的治疗预期、整合人体微生态学方面进行详细阐述,以期为认识和诊疗菌群失调相关性疾病提供新思路。
Increasing clinical evidences for the treatment of diseases with microbial reconstruction,but it is difficult for us to understand the diseases besides antibiotic-associated diseases.If we rethink the attributes of microorganisms,the limitations of tradi-tional disease classification and the integration of human microecology,we can understand the microbial reconstruction for dysbiosis-related disease better.Here we aim to elaborate the pathogenicity and probiotics of microorganisms,the extremity of fecal microbiota transplantation(FMT),the limitations of traditional disease classification,predict the clinical outcomes of remodeling gut microbiota and the integration of human microecology.It provides us the new ideas of the recognition,diagnosis and treatment for dysbiosis-relat-ed disease.
作者
张发明
ZHANG Fa-ming(Medical Center for Digestive Diseases,the Second Affiliated Hospital of Nanjing Medical University Nanjing 210011.Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第12期1233-1236,共4页
Journal of Medical Postgraduates
基金
江苏省“十三五”科教强卫工程创新团队项目(苏卫科教[2017]1号)
关键词
菌群重建
肠道菌群
益生菌
菌群失调相关性疾病
整合医学
microbial reconstruction
gut microbiota
probiotics
dysbiosis-related disease
holistic intergrativemedicine
