摘要
肾母细胞瘤(nephroblastoma)是儿童常见的腹膜后肿瘤,发病率约0.8/100000,大多数在1~3岁发病。多以腹部肿块而就诊,少部分因高血压、血尿、尿路感染、发热、厌食等原因被发现。少数患儿缺乏典型临床表现,常因肿瘤破裂和出血引起剧烈疼痛就诊。近30多年来,随着对肾母细胞瘤的深入研究及治疗水平提高,5年整体存活率由25%提高到90%,这主要归功于多学科综合治疗,但肾母细胞瘤的复发率依然高达15%。因此,早期发现肿瘤复发、转移,及时采取干预措施对其预后显得尤为重要。本文通过对肾母细胞瘤最新的治疗经验及研究做一综述,旨在优化个体化诊疗方案,加强随访,进一步提高患儿整体生存率。
Occurring mostly within 1-3 years of age,nephroblastoma is a common retroperitoneal tumor with an incidence of around 0.8/100,000.Most cases present with abdominal masses and few have hypertension,hematuria,urinary tract infection,fever and anorexia.Due to a lack of typical clinical symptoms,some cases develop severe pain due to tumor bleeding and rupture.Over the last three decades,with the in-depth mechanistic understandings and improved treatments,its 5-year overall survival has spiked from 25%to around 90%thanks to multidisciplinary interventions of chemotherapy,surgery and radiotherapy.However,its recurrent rate has hovered around 15%.Thus an early detection of tumor recurrence and metastasis is essential.This article offers a brief review of the latest treatments and researches of nephroblastoma.The objective is to optimize individual treatment protocols,strengthen their follow-ups and further improve their overall survival.
作者
蒋鸿飞(综述)
林涛石
秦林(审校)
林涛
Jiang Hongfei;Lin Tao;Shi Qinlin(Department of Pediatric Urology,Affiliated Children's Hospital,Chongqing Medical University,Chongqing 400014,China)
出处
《临床小儿外科杂志》
CAS
2020年第10期916-920,共5页
Journal of Clinical Pediatric Surgery
基金
重庆市渝中区科研项目(编号:20180155)。
