摘要
目的对扬州市报告的22例新型冠状病毒肺炎(COVID-19)确诊病例的呼吸道样本核酸检测结果及其相关因素进行分析,为COVID-19的防控提供依据。方法对确诊病例进行随访,连续5周采集咽拭子并进行核酸检测,收集基本资料,用生存分析法对数据进行统计分析。结果病例发病后1~2d、3~4d、5~7d的病毒阳性率为100%、100%、66.67%。所有病例平均核酸检测阳性时间为16.32d,其中普通型为18.50d,轻型为13.70d,对二者的阳性率进行Log-rank检验,差异有统计学意义(χ^2=4.36,P=0.037)。多因素COX回归分析显示:病例类型(OR=0.19,95%CI:0.06~0.61)、发病-就诊时间(OR=0.70,95%CI:0.55~0.88)对病例的核酸检测阳性时间有影响。结论确诊病例发病后1周内呼吸道标本阳性检出率高,轻型的核酸检测较普通型病例阳性时间短,及时就诊使用药物后可能会缩短病例的核酸检测阳性时间。
Objective To investigate the nucleic acid detection in 22 confirmed cases of coronavirus disease(COVID-19)in Yangzhou and analyze the influencing factors,and to provide evidence for the prevention and control of the disease.Method A total of 22 confirmed cases were followed up for five weeks.Throat swabs were collected for nucleic acid detection.The relevant data were collected and statistical analysis was conducted on the basis of survival analysis.Results The positive rate of throat swabs was 100%,100%and 66.67%at 1-2d,3-4d and 5-7d,respectively,after the onset of COVID-19.The average positive time of all confirmed cases was 16.32 days,including 18.50 days for common type and 13.70 days for light type.The difference was statistically significant(χ^2=4.36,P=0.037).Multivariate Cox regression analysis showed that case type(OR=0.19,95%CI:0.06-0.61)and onset visit time(OR=0.70,95%CI:0.55-0.88)had an impact on the positive time length of nucleic acid detection.Conclusion The positive rate of respiratory samples is high within one week after the onset of the confirmed cases,and the positive time length of light type cases was shorter than that of common types.The positive time length of nucleic acid detection may be shortened after timely treatment with drugs.
作者
董玉颖
王艳
黄瑶
周乐
夏候鹏
许纯
田婧棽
李秋梅
DONG Yuying;WANG Yan;HUANG Yao;ZHOU Le;TIAN Jingshen;LI Qiumei(Department of Acute Infectious Disease Control,Yangzhou Center for Disease Control and Prevention,Yangzhou,Jiangsu 225000,China)
出处
《公共卫生与预防医学》
2020年第5期15-17,共3页
Journal of Public Health and Preventive Medicine
基金
新形势下扬州地区境外输入性传染病防控机制研究项目(SRK2020000026)。
