摘要
继2003年爆发严重急性呼吸系统综合征(Severe acute respiratory syndrome,SARS)和2013年爆发中东呼吸综合征(Middle East respiratory syndrome,MERS)之后,2019年底发生的新型冠状病毒(SARS-CoV-2)疫情已构成全球大流行。许多感染者最终因多种器官衰竭死亡,其中肾损伤是病毒的主要并发症之一。肾脏损伤对于新冠肺炎患者病情判断及预后评估意义重大,肾素-血管紧张素系统(Renin-Angiotensin-System,RAS)、血管紧张素转换酶Ⅱ(angiotensin converting enzyme 2,ACE2)、细胞因子风暴、细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer 147,CD147)等与SARS-CoV-2致肾损伤机制密切相关。
Following the outbreak of Severe Acute Respiratory Syndrome(SARS)in 2003 and the outbreak of Middle East Respiratory Syndrome(MERS)in 2013,a new type of coronavirus(SARS-CoV-2)occurred at the end of 2019,which caused a global pandemic.Many infected people eventually died of multiple organ failure,among which kidney injury was one of the main complications of the virus.Kidney injury is of great significance for the condition judgment and prognosis evaluation of patients with new coronary pneumonia.Renin-Angiotensin-System(RAS),angiotensin converting enzyme 2(ACE2),cytokine storm,and extracellular matrix metalloproteinase inducer(CD147)are considered to be closely related to the mechanism of kidney injury caused by SARS-CoV-2.
作者
吕灵璐
柳赟昊
张玲
LYU Linglu;LIU Yunhao;ZHANG Ling(Department of Environmental Health and Occupational Medicine,School of Public Health,College of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China)
出处
《公共卫生与预防医学》
2020年第4期101-105,共5页
Journal of Public Health and Preventive Medicine
基金
国家自然科学基金(81671514)
湖北省自然科学基金(2018CFA040)
湖北省教育厅科学技术研究项目(Q20181105)
武汉科技大学优秀中青年团队(2018TDZ03)。
