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他汀类药物在新型冠状病毒肺炎流行期间对心血管系统及肺损伤的双重保护研究进展

The dual protective effect of statins on cardiovascular system and lung injury during the COVID-19 epidemic
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摘要 他汀类药物是心血管病患者药物治疗的基石,除降低胆固醇外,还有改善内皮功能、抑制炎症反应、抗氧化应激及血栓形成等多种作用.这些降脂以外的作用使得他汀类药物在呼吸系统疾病的治疗中也有一定的作用.在新型冠状病毒肺炎(COVID-19)流行期间,心血管病患者易感染新型冠状病毒(SARS-CoV-2).SARS-CoV-2与肺泡上皮细胞血管紧张素转换酶2(ACE2)结合,导致ACE/AngⅡ/AT1R通路活性增强,促进肺部炎症、肺血管平滑肌细胞增生、肺组织纤维化,引起肺动脉高压,严重导致急性心肺功能衰竭,增加心血管病患者病死率.鉴于他汀类药物对心肺功能的保护作用,本文通过文献分析,探讨疫情期间合并COVID-19的心血管病患者如何合理使用他汀类药物. Statins are the cornerstone of medication for cardiovascular patients.In addition to lowering cholesterol,statins have many other effects,such as improving endothelial function,inhibiting inflammatory response,resisting oxidative stress and thrombosis.These additional effects make statins have potentially important protective role in respiratory diseases as well.During the novel coronavirus pneumonia(COVID-19)epidemic,cardiovascular patients are susceptible to infect with severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).The SARS-CoV-2 binding with angiotensin converting enzyme 2(ACE2)of alveolar epithelial cells,increasing the activity of the ACE/AngⅡ/AT1R pathway,promoting pulmonary inflammatory infiltration,pulmonary vascular smooth muscle cell proliferation,pulmonary fibrosis and then cause cardio pulmonary function injury even acute failure,as a result,increasing the morbidity and mortality of cardiovascular patients.After brief review of the protective effects of statins on cardiopulmonary function,this paper mainly reviews the benefits of statins in the respiratory system to explore the rational use of statins in cardiovascular patients complicated with COVID-19 during the epidemic.
作者 王元 王智云 毕雪斐 魏首栋 邓勇志 WANG Yuan;WANG Zhi-yun;BI Xue-fei;WEI Shou-dong;DENG Yong-zhi(Department of Cardiology,Shanxi Cardiovascular Hospital,Taiyuan 030024,China;Department of Neurology,Shanxi Cardiovascular Hospital,Taiyuan 030024,China;Department of Cardiovascular Surgery,Shanxi Cardiovascular Hospital,Taiyuan 030024,China)
出处 《中国心血管病研究》 CAS 2020年第6期547-550,558,共5页 Chinese Journal of Cardiovascular Research
关键词 新型冠状病毒肺炎 新型冠状病毒 心血管疾病 他汀类药物 社区获得性肺炎 急性肺损伤 急性呼吸窘迫综合征 Novel coronavirus pneumonia(COVID-19) Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) Cardiovascular disease Statins Community acquired pneumonia Acute lung injury Acute respiratory distress syndrome
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