摘要
目的探讨围孕期叶酸补充及膳食叶酸的摄入与妊娠期高血压疾病的相关性。方法建立出生队列研究,收集2010年2月至2012年12月在甘肃省妇幼保健院建卡定期产检并随访至正常分娩的10 542例孕妇,最终以纳入的10 322例孕妇为研究对象。根据是否患有妊娠期高血压疾病将研究对象分为病例组(570例)和对照组(9 752例);根据孕妇在围孕期是否摄入叶酸补充剂分为服用叶酸补充剂组(7 608例)和未服用组(2 714例),分析围孕期叶酸补充时间及膳食中叶酸的摄入量与妊娠期高血压疾病的关系。结果病例组与对照组在年龄、家庭人均月收入、文化程度、妊娠期间是否工作、孕前身体质量指数(BMI)、孕期体重增加、孕产史、既往妊娠期高血压疾病史、是否有妊娠期糖尿病、是否多胎方面差异均有统计学意义(χ^2值分别为均33.589、49.148、44.864、16.659、92.278、44.132、15.353、14.866、10.050、221.889,均P<0.05);服用叶酸补充剂组与未服用组在文化程度、妊娠期间是否工作、家庭人均月收入、孕前BMI、孕期体重增加、孕产史、既往妊娠期高血压疾病史、是否有妊娠期糖尿病、是否多胎方面差异均有统计学意义(χ^2值分别为290.419、554.754、193.559、135.419、64.907、415.355、40.41、8.444、15.072,均P<0.001)。与围孕期均未服用叶酸补充剂的孕妇相比,在孕期服用叶酸补充剂超过12周可显著降低妊娠期高血压疾病(OR=0.56,95%CI:0.43~0.73,P<0.05)、轻度子痫前期(OR=0.29,95%CI:0.16~0.53,P<0.05)、重度子痫前期(OR=0.60,95%CI:0.39~0.91,P<0.05)及迟发型妊娠期高血压疾病(OR=0.53,95%CI:0.40~0.70,P<0.05)的发生风险;孕期高剂量膳食叶酸的摄入可降低妊娠期高血压疾病(OR=0.92,95%CI:0.84~0.99,P<0.05),特别是重度子痫前期(OR=0.85,95%CI:0.74~0.97,P<0.05)的发生风险。结论孕期服用叶酸补充剂超过12周可降低子痫前期及迟发型妊娠期高血压疾病的发生�
Objective To investigate correlation of folic acid supplementation and dietary folate intake in perigestational period with hypertensive disorder complicating pregnancy(HDCP),so as to reduce incidences of HDCP and pre-eclampsia.Methods A birth cohort study was conducted.A total of 10 542 pregnant women who received regular prenatal examination and were followed up to normal childbirth in Gansu Provincial Maternity and Child Health Hospital from February 2010 to December 2012 were selected and finally 10 322 pregnant women were enrolled as the subjects of study.According to whether the pregnant woman was suffering from HDCP,the subjects were divided into two groups:case group(n=570) and control group(n=9 752).And according to whether the pregnant woman having taken folic acid supplements in perigestational period,the subjects again were divided into the folic acid supplementation group(n=7 608) and no folic acid supplementation group(n=2 714).The correlations of folic acid supplementation time and dietary folate intake in perigestational period with HDCP were analyzed in case-control study method.Results There were significant differences in age at pregnancy,family monthly income per capita,educational background of the pregnant woman,whether having work or not during gestational period,pregestational body mass index(BMI),body weight increase during pregnancy,pregnancy and childbirth histories,past history of HDCP,whether suffering from gestational diabetes mellitus(GDM),whether having or not multiple pregnancy between the case group and the control group(χ^2=33.589,49.148,44.864,16.659,92.278,44.132,15.353,14.866,10.050 and 221.889 respectively,all P<0.05).Furthermore,there were significant differences in educational background of the pregnant woman,whether having work or not during gestational period,family monthly income per capita,pregestational body mass index(BMI),body weight increase during pregnancy,pregnancy and childbirth histories,past history of HDCP,whether suffering or not from GDM,whether having or
作者
刘小晖
何晓春
毛宝宏
董燕
刘小玲
刘兴荣
LIU Xiaohui;HE Xiaochun;MAO Baohong;DONG Yan;LIU Xiaoling;LIU Xingrong(Gansu Provincial Maternity and Child Health Hospital,Gansu Lanzhou 730050,China;School of Public Health,Lanzhou Universit y,Gansu Lanzhou 730000,China)
出处
《中国妇幼健康研究》
2020年第9期1209-1217,共9页
Chinese Journal of Woman and Child Health Research
关键词
叶酸
膳食叶酸
妊娠期高血压疾病
子痫前期
folic acid
dietary folate
hypertensive disorder complicating pregnancy(HDCP)
pre-eclampsia
