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子痫前期患者血清中sEng、sFlt-1、PLGF的表达与病情的相关性研究

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摘要 目的测定sEng(可溶性内皮因子)、sFlt-1(可溶性Fms样酪氨酸激酶-1)、PLGF(胎盘生长因子)在孕妇血清中的表达情况,并研究它们与子痫前期(PE)的发病及病情程度的相关性。方法选取我院75例子痫前期(其中35例为重度子痫前期)孕妇作为研究组,并同期随机选取40例正常孕妇(无内外科合并症及并发症)作为对照组,采用酶联免疫吸附试验分别检测对照组、研究组孕妇血清中sEng、sFlt-1、PLGF的测定值,应用SPSS 23.0软件进行统计学分析。结果重度子痫前期患者血清中的sEng、sFlt-1水平均高于正常孕妇和不伴有严重表现的子痫前期患者;不伴有严重表现的子痫前期患者血清中的sEng、sFlt-1水平均高于正常孕妇;正常孕妇的PLGF水平高于不伴有严重表现的子痫前期患者和重度子痫前期患者;不伴有严重表现的子痫前期患者的PLGF水平高于重度子痫前期患者。结论血清中sEng、sFlt-1、PLGF的水平与子痫前期的发病及病情严重程度有密切相关性,从而可以进一步指导临床的诊疗。
出处 《实用妇科内分泌电子杂志》 2020年第23期51-51,74,共2页 Electronic Journal of Practical Gynecological Endocrinology
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