摘要
目的了解孕前1年及孕期叶酸摄入与妊娠期高血压疾病的关联性,为妊娠期高血压疾病的防治提供科学依据。方法以2011-2012年在兰州市某三甲妇幼保健机构建卡并随访到正常分娩的孕妇为研究对象,用病例对照研究方法分析孕前及孕期叶酸摄入与妊娠期高血压疾病的关联性。结果在调整年龄、受教育水平、家庭人均月收入、孕前体质量指数(BMI)、孕前体质量获得、生育史、妊娠期高血压疾病史、妊娠期糖尿病、多胎、是否补充叶酸或膳食叶酸摄入等混杂因素后,与未服用叶酸补充剂的研究对象相比,孕期服用叶酸补充剂超过3个月是妊娠期高血压疾病的保护因素(OR=0.76,95%CI:0.65~0.89)。按不同时期及类型分层后,孕期补充叶酸超过3个月为晚发性妊娠期高血压疾病(OR=0.75,95%CI:0.63~0.88)及轻度子痫前期(OR=0.53,95%CI:0.38~0.74)的保护因素,而仅在孕前1年服用叶酸并不降低妊娠期高血压疾病的发生风险。结论孕期服用叶酸补充剂大于3个月可降低轻度子痫前期及晚发性妊娠期高血压疾病的发病风险,因此妇女怀孕后应长期适量服用叶酸补充剂。
Objective To investigate the correlation between folic acid supplementation at one year before pregnancy and during pregnancy and hypertensive disorder complicating pregnancy （HDCP）,provide a scientific basis for prevention and treatment of HDCP.Methods The pregnant women establishing medical records and giving birth to their babies in a grade A class 3 hospital in Lanzhou from 2011 to 2012 were selected,a case-control study was conducted to analyze the correlation between folic acid supplementation before and during pregnancy and HDCP.Results After adjusting the confounding factors （age,educational level,family monthly income per capita,pre-pregnancy body mass index,pre-pregnancy weight gain during pregnancy,childbearing history,medical history of HDCP,gestational diabetes mellitus,polyembryony,folic acid supplementation and dietary intake of focic acid）,compared with the pregnant women with folic acid supplementation,folic acid supplementation during pregnancy more than three months was the protective factor of HDCP （OR=0.76,95% CI：0.65-0.89）.After stratifying the factors according to different stages and types,folic acid supplementation during pregnancy more than three months was the protective factor of late-onset HDCP （OR=0.75,95% CI：0.63-0.88） and mild preeclampsia （OR=0.53,95% CI：0.38-0.74）.Folic acid supplementation at one year before pregnancy didn＆#39;t reduce the risk of HDCP.Condusion Folic acid supplementation during pregnancy more than three months can reduce the risk of mild preeclampsia and late-onset HDCP,so the pregnant women should supplement folic acid for a long time.
作者
毛宝宏
邱伟涛
王燕侠
王剑
王文第
裴建赢
王晶晶
刘婧婷
张春花
金玉霞
李静
MAO Bao-Hong;QIU Wei-Tao;WANG Yan-Xia;et al(Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu 730050, Chin)
出处
《中国妇幼保健》
CAS
2017年第24期6087-6091,共5页
Maternal and Child Health Care of China
基金
甘肃省自然科学研究基金计划(1208RJZA122)
关键词
叶酸
妊娠期高血压疾病
子痫前期
病例对照研究
Folic acid
Hypertensive disorder complicating pregnancy
Preeclampsia
Case-control study
