摘要
目的了解厦门地区6月龄至12岁儿童血清维生素A、维生素E及维生素D水平,为指导儿童补充维生素A、维生素D、维生素E及预防相关疾病的发生提供参考。方法于2018年11月至2019年10月,选取6 025名6月龄至12岁婴幼儿及儿童血清标本,按不同年龄、不同性别、不同季节分别进行分析。采用高效液相色谱法检测血清维生素A、维生素E水平,采用高效液相色谱串联质谱法检测血清25-羟基维生素D[25(OH)D]水平。结果 6 025例婴幼儿及儿童血清维生素A平均水平为(0.310±0.069)mg/L,维生素A不足率为39.720%,缺乏率为3.470%;血清25(OH)D平均水平为(32.794±8.435)ng/mL,维生素D不足率为4.020%,缺乏率为0.760%;血清维生素E平均水平为(10.070±2.577)mg/L,维生素E不足率为8.760%,缺乏率为0.070%。男童的血清维生素A、维生素E水平低于女童,但男童的血清25(OH)D水平高于女童(t值分别为-2.418、-9.269、4.136,均P<0.05)。不同年龄组血清维生素A、维生素E、25(OH)D水平比较差异均有统计学意义(F值分别为27.640、148.060、23.520,均P<0.05);进一步比较发现,维生素A水平在4~6岁年龄段最低,维生素D、维生素E水平在7~12岁年龄段最低,差异均有统计学意义(均P<0.05)。不同季节儿童血清维生素A、维生素E、25(OH)D水平比较差异均有统计学意义(F值分别为30.260、231.780、674.280,均P<0.05),进一步比较发现,维生素A水平夏秋两季高于冬春两季;维生素D水平夏季最高,春秋次之,冬季最低;维生素E水平夏季最高,冬季最低,差异均有统计学意义(均P<0.05)。结论厦门地区6月龄至12岁婴幼儿及儿童维生素A、维生素D、维生素E总体水平尚可。需要特别关注4~6岁年龄段儿童的维生素A补充,以及7岁以上年龄段儿童的维生素D、维生素E补充。春季应注意加强维生素A的补充,冬季则重点加强维生素D、维生素E的补充,以预防相关维生素缺乏症的发生。
Objective To understand the serum levels of vitamin A,vitamin D and vitamin E of children from 0.5 to 12 years old in Xiamen,to provide a reference for children to supplement vitamin A,vitamin D,vitamin E and prevent the occurrence of related diseases.Methods The serum of 6025 normal children aged 6 months to 12 years in Xiamen from November 2018 to October 2019 were selected and analyzed according to different ages,genders,and seasons.Vitamins A and vitamin E were detected using their sera by high-performance liquid chromatography(HPLC),and the level of 25-hydroxy vitamin D 25(OH)D was detected by high-performance liquid chromatograph-mass spectrometry(HPLC-MS/MS).Results The serum vitamin A level of 6 025 infants and children was(0.310±0.069) mg/L,the rate of insufficient detection was 39.720%,the lack rate was 3.470%.The serum 25(OH)D level was(32.794±8.435) ng/mL,the rate of insufficient detection was 4.020%,and the lack rate was 0.760%.The serum vitamin E level was(10.070±2.577) mg/L,the rate of insufficient detection was 8.760%,and the lack rate was 0.070%.The mean value of 25(OH)D in boys was significantly higher than girls(t=4.136,P<0.05),while the mean value of vitamin A and vitamin E in boys were significantly lower than girls(t=-2.418 and-9.269, respectively,both P<0.05).The differences in serum levels of vitamin A,vitamin E and 25(OH)D among children of different age groups were statistically significant(F values were 27.640,148.060 and 23.520,respectively,all P<0.05).Further comparison showed that the vitamin A level was the lowest in 4 to 6 years old,and the vitamin D and vitamin E levels were the lowest in 7 to 12 years old,and the differences were statistically significant(all P<0.05).The differences in serum levels of vitamin A,vitamin E and 25(OH)D in children in different seasons were statistically significant(F values were 30.260,231.780 and 674.280,respectively,all P<0.05).Further comparison showed that vitamin A level was higher in Summer and Autumn than that in Winter and Spring,and vita
作者
李少维
林惠玲
叶桂青
叶琳旬
林剑
李淑莲
LI Shaowei;LIN Huiling;YE Guiqing;YE Linxun;LIN Jian;LI Shulian(Maternal and Child Health Hospital of Xiamen Huli District,Fujian Xiamen 361009,China)
出处
《中国妇幼健康研究》
2020年第9期1161-1165,共5页
Chinese Journal of Woman and Child Health Research
基金
厦门市科技局科技惠民资助项目(编号3502Z20134050)
国家卫生健康委“维生素A、E水平与儿童呼吸道感染相关性研究”专项基金资助项目(编号:W2016EWQT27)。
