摘要
目的探讨非小细胞肺癌EGFR基因检测中超声引导下粗针活检的价值。方法随机选取非小细胞肺癌患者48例,所有患者均接受超声引导下粗针活检,分析穿刺结果、EGFR基因突变情况。结果48例患者中,病灶大小在1.8 cm×0.8 cm^8.0 cm×3.5 cm之间。在活检针类型方面,2例采用18G针,34例采用16G针,12例采用14G针,分别占总数的4.2%、70.8%、25.0%,取材满意率为100.0%。在病理类型方面,34例为腺癌,8例为鳞癌,4例为腺鳞癌,2例为肉瘤样癌;在并发症方面,针道少许渗血4例,咯血2例,穿刺术后并发症发生率为12.5%(6/48)。48例患者中,22例EGFR基因突变,突变率为45.8%,其中2例外显子20/21均突变、2例外显子20突变、8例外显子21突变、10例外显子19突变,分别占4.2%、4.2%、16.7%、20.8%。女性患者的EGFR基因突变率(83.3%)显著高于男性(33.3%)(P<0.05),腺癌患者的EGFR基因突变率(58.8%)显著高于非腺癌患者(14.3%)(P<0.05),但发生转移和未发生转移患者的EGFR基因突变率之间的差异不显著(P>0.05)。结论非小细胞肺癌EGFR基因检测中超声引导下粗针活检的价值高,有助于临床药物分子靶向治疗。
Objective To explore the value of ultrasound-guided core-needle biopsy in EGFR gene detection of non-small cell lung cancer.Methods 48 patients with non-small cell lung cancer(NSCLC)were randomly selected,all patients were examined by ultrasound-guided core-needle biopsy,The puncture results and EGFR gene mutation of 48 patients were analyzed.Results Among the 48 patients,the size of lesions ranged from 1.8 cm×0.8 cm to 8.0 cm×3.5 cm.In terms of biopsy needle type,18G needle was used in 2 cases,16G needle in 34 cases and 14G needle in 12 cases,which accounted for 4.2%,70.8%and 25.0%of the total,and the satisfaction rate of materials was 100.0%.In terms of pathological types,34 cases were adenocarcinoma,8 cases were squamous cell carcinoma,4 cases were adenosquamous cell carcinoma,and 2 cases were sarcomatoid cell carcinoma;In terms of complications,there were 4 cases of slight hemoptysis and 2 cases of hemoptysis.The incidence of complications after puncture was 12.5%(6/48).All of the 48 patients,22 had EGFR mutations,with a mutation rate of 45.8%,among them,2 exceptions have exon 20/21 mutation,2 exceptions have exon 20 mutation,8 exceptions have exon 21 mutation,and 10 exceptions have exon 19 mutation,which accounted for 4.2%,4.2%,16.7%and 20.8%,respectively.The EGFR mutation rate of 83.3%in female patients was significantly higher than that of 33.3%in male(P<0.05).The EGFR mutation rate of adenocarcinoma patients was 58.8%significantly higher than that of non-adenocarcinoma patients 14.3%(P<0.05),but there was no significant difference in EGFR mutation rates between patients with and without metastasis(P>0.05).Conclusion The value of ultrasound-guided core-needle biopsy in EGFR gene detection of non-small cell lung cancer is high,which is helpful for clinical drug molecular targeting therapy.
作者
刘乐
段智慧
LIU Le;DUAN Zhihui(Inner Mongolia Hospital,Hohhot,010050)
出处
《实用癌症杂志》
2020年第10期1653-1655,共3页
The Practical Journal of Cancer
基金
内蒙古自治区自然科学基金项目(编号:2017MS(LH)0856)。
